HERC4 cdna clone
HERC4 cDNA Clone
Synonyms
HERC4; HERC4 cDNA Clone; HERC4 cdna clone
Sequence
atgttgtgctggggaaatgcatcctttgggcagctaggtttgggtggaattgatgaagaaattgtactagagcccagaaaaagtgacttctttataaataaaagggtccgagatgtaggatgtggactcagacatactgtgtttgttctggatgatggaacagtgtacacatgtggatgtaatgatctaggacagctaggtcatgaaaaatccagaaagaaaccagagcaggttgttgccctggatgcccaaaatattgtagctgtttcatgtggagaagctcatacgttagcgctaaatgacaaaggccaggtgtatgcttggggtctcgattctgatggacagcttggcctggtaggatcagaggaatgcatcagagtacccagaaatattaaaagtttgtcagatatccagattgtacaggttgcttgtggttactatcattcacttgcactttctaaagcaagtgaagtcttctgttggggacagaataaatatggccaattgggtttaggtactgactgtaaaaagcaaacttcaccgcagctgcttaagtctttgcttggaatccctttcatgcaagttgcagcaggaggagcccatagttttgtactcaccctttctggagctatctttggatggggacgcaacaagtttggtcagctaggtcttaatgatgaaaatgataggtatgttcctaatttactaaagtcactaagatctcagaaaatagtttatatttgttgtggagaagatcatactgctgctctaaccaaggaaggtggagtgtttacttttggagctggagggtatggtcagttgggccataattctaccagtcatgaaataaacccaaggaaagtttttgaacttatgggaagcattgtcactgagattgcttgtggacggcagcacacttctgcttttgttccttcatcaggacgaatttactcttttgggcttggtggtaatgggcagctgggaaccggttcaacaagcaacaggaaaagcccctttactgtaaaaggaaattggtacccctataatgggcagtgtctaccagatattgattctgaagaatatttctgtgtaaaaagaattttctcagggggagatcaaagcttttcacattactctagtccccagaactgtgggccaccagatgacttcagatgtcccaatccgacaaagcagatctggacagtgaatgaagctctaattcagaaatggctgagctatccttctggaaggtttcctgtggagatagccaatgagatagatggaacgttttcttcctctggttgcctaaatggaagttttttagctgttagcaatgatgatcactatagaacaggtaccagattttcaggggttgatatgaatgctgctaggcttttattccacaaacttatacaacctgatcatccgcagatatctcagcaggtggcagctagtttggaaaagaatcttattcctaaactgactagctccttacctgatgttgaagcattgaggttttatcttactctaccagaatgtcccctgatgagtgattccaacaatttcacaacaatagcaattccctttggtacagctcttgtgaacctagaaaaggcaccactgaaagtacttgaaaactggtggtcagtacttgaacctccactattcctcaagatagtagaactttttaaggaagttgtggtacatcttttgaaactctacaagatcggtattcccccttctgaaagaagaattttcaacagttttcttcatactgcattaaaggttttagaaatactacatagggtaaatgagaaaatgggacagattatacagtatgataaattttatatacatgaagtacaagaattgatagacataagaaatgattatatcaactgggtccaacagcaggcctatggaatgttggcagatatccctgttacaatctgtacatatccatttgtatttgatgcccaagcaaaaactactctgttacagaccgatgcagtcttacagatgcagatggctattgatcaggcccacaggcagaatgtctcctctctttttctcccagtgattgaatctgtgaatccctgcttaattctagtggtgcgtagagaaaatattgtaggagatgcaatggaagtccttaggaaaacaaagaacatagattacaagaagccactcaaggttatatttgttggagaagatgctgtggatgcaggaggggtgcgcaaagaatttttcttgctcatcatgagggaattattggatcctaaatacggcatgtttaggtattatgaagattccaggctcatttggttttctgataagacatttgaagacagtgatttgttccatttgattggtgttatctgtggcttagcaatttataattgtaccattgtggacctccattttcctttggctttatataagaaactactgaaaaagaagccatccttggatgatttgaaagaactaatgcctgatgttgggagaagcatgcaacagttactggattatccagaagatgacatagaggaaacattttgtcttaattttacgatcacagttgaaaactttggtgcaacagaagtgaaagagctggttctaaatggtgcagacacagctgttaacaaacaaaatcggcaagagtttgtcgatgcttatgtggattacatattcaataaatcagtggcttccttatttgatgcttttcatgcgggctttcataaggtctgtggaggaaaagtccttctgctctttcagcctaatgaactacaagcaatggtcattggaaatacaaattatgattggaaggaactggaaaagaatacagaatacaaaggggaatattgggcagaacatcctacgataaaaattttttgggaagtatttcacgaattaccattggaaaagaagaaacagtttctgttatttttgacaggtagtgatcgcattcctattcttggtatgaagagtctgaaactagtcatccagtccacaggaggtggtgaggagtatctcccagtttcccatacttgttttaatcttctggatcttccaaaatatacagaaaaagaaactctacgctctaaactgatccaagctattgatcacaatgaaggcttcagtttaatataa
Sequence Length
3150
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
106,715 Da
NCBI Official Full Name
Homo sapiens hect domain and RLD 4, mRNA
NCBI Official Synonym Full Names
HECT and RLD domain containing E3 ubiquitin protein ligase 4
NCBI Official Symbol
HERC4
NCBI Protein Information
probable E3 ubiquitin-protein ligase HERC4
UniProt Protein Name
Probable E3 ubiquitin-protein ligase HERC4
Protein Family
UniProt Gene Name
HERC4
UniProt Synonym Gene Names
KIAA1593
UniProt Entry Name
HERC4_HUMAN
NCBI Description
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Uniprot Description
HERC4: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component: cytoplasm; nucleus
Molecular Function: ubiquitin-protein ligase activity
Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process; spermatogenesis
Research Articles on HERC4
Similar Products
Product Notes
The HERC4 herc4 (Catalog #AAA1277923) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgttgtgct ggggaaatgc atcctttggg cagctaggtt tgggtggaat tgatgaagaa attgtactag agcccagaaa aagtgacttc tttataaata aaagggtccg agatgtagga tgtggactca gacatactgt gtttgttctg gatgatggaa cagtgtacac atgtggatgt aatgatctag gacagctagg tcatgaaaaa tccagaaaga aaccagagca ggttgttgcc ctggatgccc aaaatattgt agctgtttca tgtggagaag ctcatacgtt agcgctaaat gacaaaggcc aggtgtatgc ttggggtctc gattctgatg gacagcttgg cctggtagga tcagaggaat gcatcagagt acccagaaat attaaaagtt tgtcagatat ccagattgta caggttgctt gtggttacta tcattcactt gcactttcta aagcaagtga agtcttctgt tggggacaga ataaatatgg ccaattgggt ttaggtactg actgtaaaaa gcaaacttca ccgcagctgc ttaagtcttt gcttggaatc cctttcatgc aagttgcagc aggaggagcc catagttttg tactcaccct ttctggagct atctttggat ggggacgcaa caagtttggt cagctaggtc ttaatgatga aaatgatagg tatgttccta atttactaaa gtcactaaga tctcagaaaa tagtttatat ttgttgtgga gaagatcata ctgctgctct aaccaaggaa ggtggagtgt ttacttttgg agctggaggg tatggtcagt tgggccataa ttctaccagt catgaaataa acccaaggaa agtttttgaa cttatgggaa gcattgtcac tgagattgct tgtggacggc agcacacttc tgcttttgtt ccttcatcag gacgaattta ctcttttggg cttggtggta atgggcagct gggaaccggt tcaacaagca acaggaaaag cccctttact gtaaaaggaa attggtaccc ctataatggg cagtgtctac cagatattga ttctgaagaa tatttctgtg taaaaagaat tttctcaggg ggagatcaaa gcttttcaca ttactctagt ccccagaact gtgggccacc agatgacttc agatgtccca atccgacaaa gcagatctgg acagtgaatg aagctctaat tcagaaatgg ctgagctatc cttctggaag gtttcctgtg gagatagcca atgagataga tggaacgttt tcttcctctg gttgcctaaa tggaagtttt ttagctgtta gcaatgatga tcactataga acaggtacca gattttcagg ggttgatatg aatgctgcta ggcttttatt ccacaaactt atacaacctg atcatccgca gatatctcag caggtggcag ctagtttgga aaagaatctt attcctaaac tgactagctc cttacctgat gttgaagcat tgaggtttta tcttactcta ccagaatgtc ccctgatgag tgattccaac aatttcacaa caatagcaat tccctttggt acagctcttg tgaacctaga aaaggcacca ctgaaagtac ttgaaaactg gtggtcagta cttgaacctc cactattcct caagatagta gaacttttta aggaagttgt ggtacatctt ttgaaactct acaagatcgg tattccccct tctgaaagaa gaattttcaa cagttttctt catactgcat taaaggtttt agaaatacta catagggtaa atgagaaaat gggacagatt atacagtatg ataaatttta tatacatgaa gtacaagaat tgatagacat aagaaatgat tatatcaact gggtccaaca gcaggcctat ggaatgttgg cagatatccc tgttacaatc tgtacatatc catttgtatt tgatgcccaa gcaaaaacta ctctgttaca gaccgatgca gtcttacaga tgcagatggc tattgatcag gcccacaggc agaatgtctc ctctcttttt ctcccagtga ttgaatctgt gaatccctgc ttaattctag tggtgcgtag agaaaatatt gtaggagatg caatggaagt ccttaggaaa acaaagaaca tagattacaa gaagccactc aaggttatat ttgttggaga agatgctgtg gatgcaggag gggtgcgcaa agaatttttc ttgctcatca tgagggaatt attggatcct aaatacggca tgtttaggta ttatgaagat tccaggctca tttggttttc tgataagaca tttgaagaca gtgatttgtt ccatttgatt ggtgttatct gtggcttagc aatttataat tgtaccattg tggacctcca ttttcctttg gctttatata agaaactact gaaaaagaag ccatccttgg atgatttgaa agaactaatg cctgatgttg ggagaagcat gcaacagtta ctggattatc cagaagatga catagaggaa acattttgtc ttaattttac gatcacagtt gaaaactttg gtgcaacaga agtgaaagag ctggttctaa atggtgcaga cacagctgtt aacaaacaaa atcggcaaga gtttgtcgat gcttatgtgg attacatatt caataaatca gtggcttcct tatttgatgc ttttcatgcg ggctttcata aggtctgtgg aggaaaagtc cttctgctct ttcagcctaa tgaactacaa gcaatggtca ttggaaatac aaattatgat tggaaggaac tggaaaagaa tacagaatac aaaggggaat attgggcaga acatcctacg ataaaaattt tttgggaagt atttcacgaa ttaccattgg aaaagaagaa acagtttctg ttatttttga caggtagtga tcgcattcct attcttggta tgaagagtct gaaactagtc atccagtcca caggaggtgg tgaggagtat ctcccagttt cccatacttg ttttaatctt ctggatcttc caaaatatac agaaaaagaa actctacgct ctaaactgat ccaagctatt gatcacaatg aaggcttcag tttaatataa. It is sometimes possible for the material contained within the vial of "HERC4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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