GZMH cdna clone
GZMH cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]
Uniprot Description
GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.
Protein type: Protease; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane
Molecular Function: serine-type endopeptidase activity
Biological Process: immune response; protein processing
Research Articles on GZMH
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Product Notes
The GZMH gzmh (Catalog #AAA1278318) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcagccat tcctcctcct gttggccttt cttctgaccc ctggggctgg gacagaggag atcatcgggg gccatgaggc caagccccac tcccgcccct acatggcctt tgttcagttt ctgcaagaga agagtcggaa gaggtgtggc ggcatcctag tgagaaagga ctttgtgctg acagctgctc actgccaggg aagctccata aatgtcacct tgggggccca caatatcaag gaacaggagc ggacccagca gtttatccct gtgaaaagac ccatccccca tccagcctat aatcctaaga acttctccaa cgacatcatg ctactgcagc tggagagaaa ggccaagtgg accacagctg tgcggcctct caggctacct agcagcaagg cccaggtgaa gccagggcag ctgtgcagtg tggctggctg gggttatgtc tcaatgagca ctttagcaac cacactgcag gaagtgttgc tgacagtgca gaaggactgc cagtgtgaac gtctcttcca tggcaattac agcagagcca ctgagatttg tgtgggggat ccaaagaaga cacagaccgg tttcaagggg gactccgggg ggcccctcgt gtgtaaggac gtagcccaag gtattctctc ctatggaaac aaaaaaggga cacctccagg agtctacatc aaggtctcac acttcctgcc ctggataaag agaacaatga agcgcctcta a. It is sometimes possible for the material contained within the vial of "GZMH, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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