GRIN2C cdna clone
GRIN2C cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Description
NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane
Molecular Function: protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: glutamate signaling pathway; MAPKKK cascade; synaptic transmission; transport
Research Articles on GRIN2C
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Product Notes
The GRIN2C grin2c (Catalog #AAA1271507) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggtgggg ccctggggcc ggccctgttg ctcacctcgc tcttcggtgc ctgggcaggg ctgggtccgg ggcagggcga gcagggcatg acggtggccg tggtgtttag cagctcaggg ccgccccagg cccagttccg tgcccgcctc accccccaga gcttcctgga cctacccctg gagatccagc cgctcacagt tggggtcaac accaccaacc ccagcagcct cctcacccag atctgcggcc tcctgggtgc tgcccacgtc cacggcattg tctttgagga caacgtggac accgaggcgg tggcccagat ccttgacttc atctcctccc agacccatgt gcccatcctc agcatcagcg gaggctctgc tgtggtcctc acccccaagg tgcatgtcca aactcatgtc ccctcgtgcc tcaggcctgg aaccaggctg gggtcggggg tgctttggtt ctgggaagct gggattagac gggatgggca gggaggtggg ggctga. It is sometimes possible for the material contained within the vial of "GRIN2C, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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