GRIN2A cdna clone
GRIN2A cDNA Clone
Gene Names
GRIN2A; LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
Synonyms
GRIN2A; GRIN2A cDNA Clone; GRIN2A cdna clone
Sequence
atgggcagagtgggctattggaccctgctggtgctgccggcccttctggtctggcgcggtccggcgccgagcgcggcggcggagaagggtccccccgcgctaaatattgcggtgatgctgggtcacagccacgacgtgacagagcgcgaacttcgaacactgtggggccccgagcaggcggcggggctgcccctggacgtgaacgtggtagctctgctgatgaaccgcaccgaccccaagagcctcatcacgcacgtgtgcgacctcatgtccggggcacgcatccacggcctcgtgtttggggacgacacggaccaggaggccgtagcccagatgctggattttatctcctcccacaccttcgtccccatcttgggcattcatgggggcgcatctatgatcatggctgacaaggatccgacgtctaccttcttccagtttggagcgtccatccagcagcaagccacggtcatgctgaagatcatgcaggattatgactggcatgtcttctccctggtgaccactatcttccctggctacagggaattcatcagcttcgtcaagaccacagtggacaacagctttgtgggctgggacatgcagaatgtgatcacactggacacttcctttgaggatgcaaagacacaagtccagctgaagaagatccactcttctgtcatcttgctctactgttccaaagacgaggctgttctcattctgagtgaggcccgctcccttggcctcaccgggtatgatttcttctggattgtccccagcttggtctctgggaacacggagctcatcccaaaagagtttccatcgggactcatttctgtctcctacgatgactgggactacagcctggaggcgagagtgagggacggcattggcatcctaaccaccgctgcatcttctatgctggagaagttctcctacatccccgaggccaaggccagctgctacgggcagatggagaggccagaggtcccgatgcacaccttgcacccatttatggtcaatgttacatgggatggcaaagacttatccttcactgaggaaggctaccaggtgcaccccaggctggtggtgattgtgctgaacaaagaccgggaatgggaaaaggtgggcaagtgggagaaccatacgctgagcctgaggcacgccgtgtggcccaggtacaagtccttctccgactgtgagccggatgacaaccatctcagcatcgtcaccctggaggaggccccattcgtcatcgtggaagacatagaccccctgaccgagacgtgtgtgaggaacaccgtgccatgtcggaagttcgtcaaaatcaacaattcaaccaatgaggggatgaatgtgaagaaatgctgcaaggggttctgcattgatattctgaagaagctttccagaactgtgaagtttacttacgacctctatctggtgaccaatgggaagcatggcaagaaagttaacaatgtgtggaatggaatgatcggtgaagtggtctatcaacgggcagtcatggcagttggctcgctcaccatcaatgaggaacgttctgaagtggtggacttctctgtgccctttgtggaaacgggaatcagtgtcatggtttcaagaagtaatggcaccgtctcaccttctgcttttctagaaccattcagcgcctctgtctgggtgatgatgtttgtgatgctgctcattgtttctgccatagctgtttttgtctttgaatacttcagccctgttggatacaacagaaacttagccaaagggaaagcaccccatgggccttcttttacaattggaaaagctatatggcttctttggggcctggtgttcaataactccgtgcctgtccagaatcctaaagggaccaccagcaagatcatggtatctgtatgggccttcttcgctgtcatattcctggctagctacacagccaatctggctgccttcatgatccaagaggaatttgtggaccaagtgaccggcctcagtgacaaaaagtttcagagacctcatgactattccccaccttttcgatttgggacagtgcctaatggaagcacggagagaaacattcggaataactatccctacatgcatcagtacatgaccaaatttaatcagaaaggagtagaggacgccttggtcagcctgaaaacggggaagctggacgctttcatctacgatgccgcagtcttgaattacaaggctgggagggatgaaggctgcaagctggtgaccatcgggagtgggtacatctttgccaccaccggttatggaattgcccttcagaaaggctctccttggaagaggcagatcgacctggccttgcttcagtttgtgggtgatggtgagatggaggagctggagaccctgtggctcactgggatctgccacaacgagaagaacgaggtgatgagcagccagctggacattgacaacatggcgggcgtattctacatgctggctgccgccatggcccttagcctcatcaccttcatctgggagcacctcttctactggaagctgcgcttctgtttcacgggcgtgtgctccgaccggcctgggttgctcttctccatcagcaggggcatctacagctgcattcatggagtgcacattgaagaaaagaagaagtctccagacttcaatctgacgggatcccagagcaacatgttaaaactcctccggtcagccaaaaacatttccagcatgtccaacatgaactcctcaagaatggactcacccaaaagagctgctgacttcatccaaagaggttccctcatcatggacatggtttcagataaggggaatttgatgtactcagacaacaggtcctttcaggggaaagagagcatttttggagacaacatgaacgaactccaaacatttgtggccaaccggcagaaggataacctcaataactatgtattccagggacaacatcctcttactctcaatgagtccaaccctaacacggtggaggtggccgtgagcacagaatccaaagcgaactctagaccccggcagctgtggaagaaatccgtggattccatacgccaggattcactatcccagaatccagtctcccagagggatgaggcaacagcagagaataggacccactccctaaagagccctaggtatcttccagaagagatggcccactctgacatttcagaaacgtcaaatcgggccacgtgccacagggaacctgacaacagtaagaaccacaaaaccaaggacaactttaaaaggtcagtggcctccaaataccccaaggactgtagtgaggtcgagcgcacctacctgaaaaccaaatcaagctcccctagagacaagatctacactatagatggtgagaaggagcctggtttccacttagatccaccccagtttgttgaaaatgtgaccctgcccgagaacgtggacttcccggacccctaccaggatcccagtgaaaacttccgcaagggggactccacgctgccaatgaaccggaaccccttgcataatgaagaggggctttccaacaacgaccagtataaactctactccaagcacttcaccttgaaagacaagggttccccgcacagtgagaccagcgagcgataccggcagaactccacgcactgcagaagctgcctttccaacatgcccacctattcaggccacttcaccatgaggtcccccttcaagtgcgatgcctgcctgcggatggggaacctctatgacatcgatgaagaccagatgcttcaggagacagggatgaccaacgcttggttattgggagatgcccctcggacccttacaaacactcgttgccatcccaggcggtga
Sequence Length
3846
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
144,431 Da
NCBI Official Full Name
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2A, mRNA
NCBI Official Synonym Full Names
glutamate ionotropic receptor NMDA type subunit 2A
NCBI Official Symbol
GRIN2A
NCBI Official Synonym Symbols
LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2A
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2A
Protein Family
UniProt Gene Name
GRIN2A
UniProt Synonym Gene Names
NMDAR2A; GluN2A; NMDAR2A; NR2A; hNR2A
UniProt Entry Name
NMDE1_HUMAN
NCBI Description
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.
Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p13.2
Cellular Component: cell surface; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane
Molecular Function: protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process: glutamate signaling pathway; learning and/or memory; MAPKKK cascade; response to ethanol; synaptic transmission; transport
Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation
Research Articles on GRIN2A
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Product Notes
The GRIN2A grin2a (Catalog #AAA1267670) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggcagag tgggctattg gaccctgctg gtgctgccgg cccttctggt ctggcgcggt ccggcgccga gcgcggcggc ggagaagggt ccccccgcgc taaatattgc ggtgatgctg ggtcacagcc acgacgtgac agagcgcgaa cttcgaacac tgtggggccc cgagcaggcg gcggggctgc ccctggacgt gaacgtggta gctctgctga tgaaccgcac cgaccccaag agcctcatca cgcacgtgtg cgacctcatg tccggggcac gcatccacgg cctcgtgttt ggggacgaca cggaccagga ggccgtagcc cagatgctgg attttatctc ctcccacacc ttcgtcccca tcttgggcat tcatgggggc gcatctatga tcatggctga caaggatccg acgtctacct tcttccagtt tggagcgtcc atccagcagc aagccacggt catgctgaag atcatgcagg attatgactg gcatgtcttc tccctggtga ccactatctt ccctggctac agggaattca tcagcttcgt caagaccaca gtggacaaca gctttgtggg ctgggacatg cagaatgtga tcacactgga cacttccttt gaggatgcaa agacacaagt ccagctgaag aagatccact cttctgtcat cttgctctac tgttccaaag acgaggctgt tctcattctg agtgaggccc gctcccttgg cctcaccggg tatgatttct tctggattgt ccccagcttg gtctctggga acacggagct catcccaaaa gagtttccat cgggactcat ttctgtctcc tacgatgact gggactacag cctggaggcg agagtgaggg acggcattgg catcctaacc accgctgcat cttctatgct ggagaagttc tcctacatcc ccgaggccaa ggccagctgc tacgggcaga tggagaggcc agaggtcccg atgcacacct tgcacccatt tatggtcaat gttacatggg atggcaaaga cttatccttc actgaggaag gctaccaggt gcaccccagg ctggtggtga ttgtgctgaa caaagaccgg gaatgggaaa aggtgggcaa gtgggagaac catacgctga gcctgaggca cgccgtgtgg cccaggtaca agtccttctc cgactgtgag ccggatgaca accatctcag catcgtcacc ctggaggagg ccccattcgt catcgtggaa gacatagacc ccctgaccga gacgtgtgtg aggaacaccg tgccatgtcg gaagttcgtc aaaatcaaca attcaaccaa tgaggggatg aatgtgaaga aatgctgcaa ggggttctgc attgatattc tgaagaagct ttccagaact gtgaagttta cttacgacct ctatctggtg accaatggga agcatggcaa gaaagttaac aatgtgtgga atggaatgat cggtgaagtg gtctatcaac gggcagtcat ggcagttggc tcgctcacca tcaatgagga acgttctgaa gtggtggact tctctgtgcc ctttgtggaa acgggaatca gtgtcatggt ttcaagaagt aatggcaccg tctcaccttc tgcttttcta gaaccattca gcgcctctgt ctgggtgatg atgtttgtga tgctgctcat tgtttctgcc atagctgttt ttgtctttga atacttcagc cctgttggat acaacagaaa cttagccaaa gggaaagcac cccatgggcc ttcttttaca attggaaaag ctatatggct tctttggggc ctggtgttca ataactccgt gcctgtccag aatcctaaag ggaccaccag caagatcatg gtatctgtat gggccttctt cgctgtcata ttcctggcta gctacacagc caatctggct gccttcatga tccaagagga atttgtggac caagtgaccg gcctcagtga caaaaagttt cagagacctc atgactattc cccacctttt cgatttggga cagtgcctaa tggaagcacg gagagaaaca ttcggaataa ctatccctac atgcatcagt acatgaccaa atttaatcag aaaggagtag aggacgcctt ggtcagcctg aaaacgggga agctggacgc tttcatctac gatgccgcag tcttgaatta caaggctggg agggatgaag gctgcaagct ggtgaccatc gggagtgggt acatctttgc caccaccggt tatggaattg cccttcagaa aggctctcct tggaagaggc agatcgacct ggccttgctt cagtttgtgg gtgatggtga gatggaggag ctggagaccc tgtggctcac tgggatctgc cacaacgaga agaacgaggt gatgagcagc cagctggaca ttgacaacat ggcgggcgta ttctacatgc tggctgccgc catggccctt agcctcatca ccttcatctg ggagcacctc ttctactgga agctgcgctt ctgtttcacg ggcgtgtgct ccgaccggcc tgggttgctc ttctccatca gcaggggcat ctacagctgc attcatggag tgcacattga agaaaagaag aagtctccag acttcaatct gacgggatcc cagagcaaca tgttaaaact cctccggtca gccaaaaaca tttccagcat gtccaacatg aactcctcaa gaatggactc acccaaaaga gctgctgact tcatccaaag aggttccctc atcatggaca tggtttcaga taaggggaat ttgatgtact cagacaacag gtcctttcag gggaaagaga gcatttttgg agacaacatg aacgaactcc aaacatttgt ggccaaccgg cagaaggata acctcaataa ctatgtattc cagggacaac atcctcttac tctcaatgag tccaacccta acacggtgga ggtggccgtg agcacagaat ccaaagcgaa ctctagaccc cggcagctgt ggaagaaatc cgtggattcc atacgccagg attcactatc ccagaatcca gtctcccaga gggatgaggc aacagcagag aataggaccc actccctaaa gagccctagg tatcttccag aagagatggc ccactctgac atttcagaaa cgtcaaatcg ggccacgtgc cacagggaac ctgacaacag taagaaccac aaaaccaagg acaactttaa aaggtcagtg gcctccaaat accccaagga ctgtagtgag gtcgagcgca cctacctgaa aaccaaatca agctccccta gagacaagat ctacactata gatggtgaga aggagcctgg tttccactta gatccacccc agtttgttga aaatgtgacc ctgcccgaga acgtggactt cccggacccc taccaggatc ccagtgaaaa cttccgcaag ggggactcca cgctgccaat gaaccggaac cccttgcata atgaagaggg gctttccaac aacgaccagt ataaactcta ctccaagcac ttcaccttga aagacaaggg ttccccgcac agtgagacca gcgagcgata ccggcagaac tccacgcact gcagaagctg cctttccaac atgcccacct attcaggcca cttcaccatg aggtccccct tcaagtgcga tgcctgcctg cggatgggga acctctatga catcgatgaa gaccagatgc ttcaggagac agggatgacc aacgcttggt tattgggaga tgcccctcgg acccttacaa acactcgttg ccatcccagg cggtga. It is sometimes possible for the material contained within the vial of "GRIN2A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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