GRIA1 cdna clone
GRIA1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: cell soma; cell surface; dendrite; dendritic spine; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; plasma membrane; postsynaptic density; recycling endosome
Molecular Function: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; excitatory extracellular ligand-gated ion channel activity; glutamate receptor activity; PDZ domain binding; protein binding
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; signal transduction; synaptic transmission
Research Articles on GRIA1
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Product Notes
The GRIA1 gria1 (Catalog #AAA1277791) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCAGCACA TTTTTGCCTT CTTCTGCACC GGTTTCCTAG GCGCGGTAGT AGGTGCCAAT TTCCCCAACA ATATCCAGAT CGGGGGATTA TTTCCAAACC AGCAGTCACA GGAACATGCT GCTTTTAGAT TTGCTTTGTC GCAACTCACA GAGCCCCCGA AGCTGCTCCC CCAGATTGAT ATTGTGAACA TCAGCGACAG CTTTGAGATG ACCTATAGAT TCTGTTCCCA GTTCTCCAAA GGAGTCTATG CCATCTTTGG GTTTTATGAA CGTAGGACTG TCAACATGCT GACCTCCTTT TGTGGGGCCC TCCACGTCTG CTTCATTACG CCGAGCTTTC CCGTTGATAC ATCCAATCAG TTTGTCCTTC AGCTGCGCCC TGAACTGCAG GATGCCCTCA TCAGCATCAT TGACCATTAC AAGTGGCAGA AATTTGTCTA CATTTATGAT GCCGACCGGG GCTTATCCGT CCTGCAGAAA GTCCTGGATA CAGCTGCTGA GAAGAACTGG CAGGTGACAG CAGTCAACAT CTTGACAACC ACAGAGGAGG GATACCGGAT GCTCTTTCAG GACCTGGAGA AGAAAAAGGA GCGGCTGGTG GTGGTGGACT GTGAATCAGA ACGCCTCAAT GCTATCTTGG GCCAGATTAT AAAGCTAGAG AAGAATGGCA TCGGCTACCA CTACATTCTT GCAAATCTGG GCTTCATGGA CATTGACTTA AACAAATTCA AGGAGAGTGG CGCCAATGTG ACAGGTTTCC AGCTGGTGAA CTACACAGAC ACTATTCCGG CCAAGATCAT GCAGCAGTGG AAGAATAGTG ATGCTCGAGA CCACACACGG GTGGACTGGA AGAGACCCAA GTACACCTCT GCGCTCACCT ACGATGGGGT GAAGGTGATG GCTGAGGCTT TCCAGAGCCT GCGGAGGCAG AGAATTGATA TATCTCGCCG GGGGAATGCT GGGGATTGTC TGGCTAACCC AGCTGTTCCC TGGGGCCAAG GGATCGACAT CCAGAGAGCT CTGCAGCAGG TGCGATTTGA AGGTTTAACA GGAAACGTGC AGTTTAATGA GAAAGGACGC CGGACCAACT ACACGCTCCA CGTGATTGAA ATGAAACATG ACGGCATCCG AAAGATTGGT TACTGGAATG AAGATGATAA GTTTGTCCCT GCAGCCACCG ATGCCCAAGC TGGGGGCGAT AATTCAAGTG TTCAGAACAG AACATACATC GTCACAACAA TCCTAGAAGA TCCTTATGTG ATGCTCAAGA AGAACGCCAA TCAGTTTGAG GGCAATGACC GTTACGAGGG CTACTGTGTA GAGCTGGCGG CAGAGATTGC CAAGCACGTG GGCTACTCCT ACCGTCTGGA GATTGTCAGT GATGGAAAAT ACGGAGCCCG AGACCCTGAC ACGAAGGCCT GGAATGGCAT GGTGGGAGAG CTGGTCTATG GAAGAGCAGA TGTGGCTGTG GCTCCCTTAA CTATCACTTT GGTCCGGGAA GAAGTTATAG ATTTCTCCAA ACCATTTATG AGTTTGGGGA TCTCCATCAT GATTAAAAAA CCACAGAAAT CCAAGCCGGG TGTCTTCTCC TTCCTTGATC CTTTGGCTTA TGAGATTTGG ATGTGCATTG TTTTTGCCTA CATTGGAGTG AGTGTTGTCC TCTTCCTGGT CAGCCGCTTC AGTCCCTATG AATGGCACAG TGAAGAGTTT GAGGAAGGAC GGGACCAGAC AACCAGTGAC CAGTCCAATG AGTTTGGGAT ATTCAACAGT TTGTGGTTCT CCCTGGGAGC CTTCATGCAG CAAGGATGTG ACATTTCTCC CAGGTCCCTG TCTGGTCGCA TCGTTGGTGG CGTCTGGTGG TTCTTCACCT TAATCATCAT CTCCTCATAT ACAGCCAATC TGGCCGCCTT CCTGACCGTG GAGAGGATGG TGTCTCCCAT TGAGAGTGCA GAGGACCTAG CGAAGCAGAC AGAAATTGCC TACGGGACGC TGGAAGCAGG ATCTACTAAG GAGTTCTTCA GGAGGTCTAA AATTGCTGTG TTTGAGAAGA TGTGGACATA CATGAAGTCA GCAGAGCCAT CAGTTTTTGT GCGGACCACA GAGGAGGGGA TGATTCGAGT GAGGAAATCC AAAGGCAAAT ATGCCTACCT CCTGGAGTCC ACCATGAATG AGTACATTGA GCAGCGGAAA CCCTGTGACA CCATGAAGGT GGGAGGTAAC TTGGATTCCA AAGGCTATGG CATTGCAACA CCCAAGGGGT CTGCCCTGAG AAATCCAGTA AACCTGGCAG TGTTAAAACT GAACGAGCAG GGGCTTTTGG ACAAATTGAA AAACAAATGG TGGTACGACA AGGGCGAGTG CGGCAGCGGG GGAGGTGATT CCAAGGACAA GACAAGCGCT CTGAGCCTCA GCAATGTGGC AGGCGTGTTC TACATCCTGA TCGGAGGACT TGGACTAGCC ATGCTGGTTG CCTTAATCGA GTTCTGCTAC AAATCCCGTA GTGAATCCAA GCGGATGAAG GGTTTTTGTT TGATCCCACA GCAATCCATC AACGAAGCCA TACGGACATC GACCCTCCCC CGCAACAGCG GGGCAGGAGC CAGCAGCGGC GGCAGTGGAG AGAATGGTCG GGTGGTCAGC CATGACTTCC CCAAGTCCAT GCAATCGATT CCTTGCATGA GCCACAGTTC AGGGATGCCC TTGGGAGCCA CGGGATTGTA A. It is sometimes possible for the material contained within the vial of "GRIA1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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