GRAP2 cdna clone

GRAP2

Cat. Num. AAA200520

• Gene Names: GRAP2; P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
• Synonyms: GRAP2; GADS; GRAP-2; GRB2L; GRBLG; GrbX; Grf40; GRID; GRPL; Mona; P38; GRAP2 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGAAGCTG TTGCCAAGTT TGATTTCACT GCTTCAGGTG AGGATGAACT GAGCTTTCAC ACTGGAGATG TTTTGAAGAT TTTAAGTAAC CAAGAGGAGT GGTTTAAGGC GGAGCTTGGG AGCCAGGAAG GATATGTGCC CAAGAATTTC ATAGACATCC AGTTTCCCAA ATGGTTTCAC GAAGGCCTCT CTCGACACCA GGCAGAGAAC TTACTCATGG GCAAGGAGGT TGGCTTCTTC ATCATCCGGG CCAGCCAGAG CTCCCCAGGG GACTTCTCCA TCTCTGTCAG GCATGAGGAT GACGTTCAAC ACTTCAAGGT CATGCGAGAC AACAAGGGTA ATTACTTTCT GTGGACTGAG AAGTTTCCAT CCCTAAATAA GCTGGTAGAC TACTACAGGA CAAATTCCAT CTCCAGACAG AAGCAGATCT TCCTTAGAGA CAGAACCCGA GAAGACCAGG GTCACCGGGG CAACAGCCTG GACCGGAGGT CCCAGGGAGG CCCACACCTC AGTGGGGCTG TGGGAGAAGA AATCCGACCT TCGATGAACC GGAAGCTGTC GGATCACCCC CCGACCCTTC CCCTGCAGCA GCACCAGCAC CAGCCACAGC CTCCGCAATA TGCCCCAGCG CCCCAGCAGC TGCAGCAGCC CCCACAGCAG CGATATCTGC AGCACCACCA TTTCCACCAG GAACGCCGAG GAGGCAGCCT TGACATAAAT GATGGGCATT GTGGCACCGG CTTGGGCAGT GAAATGAATG CGGCCCTCAT GCATCGGAGA CACACAGACC CAGTGCAGCT CCAGGCGGCA GGGCGAGTGC GGTGGGCCCG GGCGCTGTAT GACTTTGAGG CCCTGGAGGA TGACGAGCTG GGGTTCCACA GCGGGGAGGT GGTGGAGGTC CTGGATAGCT CCAACCCATC CTGGTGGACC GGCCGCCTGC ACAACAAGCT GGGCCTCTTC CCTGCCAACT ACGTGGCACC CATGACCCGA TAA; ; Translation Sequence: MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF IDIQFPKWFH EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP SMNRKLSDHP PTLPLQQHQH QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN DGHCGTGLGS EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV LDSSNPSWWT GRLHNKLGLF PANYVAPMTR
• Sequence Length: 330

• Species: Human
• Chromosome Location: 22q13.2
• OMIM Reference Number: 604518
• cDNA Size: 993bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for GRAP2 cdna clone

GRAP2, also known as GADS, is a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains.

Product Categories/Family for GRAP2 cdna clone

Cancer; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4758476
• NCBI GeneID: 9402
• NCBI Accession #: NP_004801.1
• NCBI GenBank Nucleotide #: NM_004810.3
• UniProt Accession #: O75791
• NCBI Official Full Name: GRB2-related adapter protein 2 isoform 1
• NCBI Official Synonym Full Names: GRB2 related adaptor protein 2
• NCBI Official Symbol: GRAP2
• NCBI Official Synonym Symbols: P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
• NCBI Protein Information: GRB2-related adapter protein 2
• UniProt Protein Name: GRB2-related adapter protein 2
• Protein Family: GRB2-related adapter protein
• UniProt Gene Name: GRAP2
• UniProt Synonym Gene Names: GADS; GRB2L; GRID; GRB2L; Grf-40
• UniProt Entry Name: GRAP2_HUMAN

NCBI Description

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Description

GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; endosome

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of signal transduction; cell-cell signaling; Ras protein signal transduction; T cell costimulation; innate immune response; T cell receptor signaling pathway