GNAO1 cdna clone
GNAO1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Description
G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: heterotrimeric G-protein complex; plasma membrane
Molecular Function: corticotropin-releasing hormone receptor 1 binding; G-protein beta/gamma-subunit binding; GTP binding; GTPase activity; metabotropic serotonin receptor binding; mu-type opioid receptor binding; signal transducer activity
Biological Process: dopamine receptor signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; muscle contraction; protein folding; Wnt receptor signaling pathway, calcium modulating pathway
Disease: Epileptic Encephalopathy, Early Infantile, 17
Research Articles on GNAO1
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Product Notes
The GNAO1 gnao1 (Catalog #AAA1275265) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagatca tccatgaaga tggcttctcc ggagaagacg tgaaacagta caagcctgtt gtctacagca acactatcca gtccctggca gccatcgtcc gggccatgga cactttgggc atcgaatatg gtgataagga gagaaaggct gacgccaaga tggtgtgtga tgtggtgagt cggatggaag acaccgagcc cttctctgca gagctgcttt ctgccatgat gcggctctgg ggcgactcag gaatccaaga gtgcttcaac cggtcccggg agtatcagct caacgactct gccaaatact acctggacag cctggatcgg attggggccg ccgactacca gcccaccgag caggacatcc tccgaaccag ggtcaaaacc actggcatcg tagaaaccca cttcacattc aagaacctcc acttcaggct gtttgacgtc ggaggccagc gatctgaacg caagaagtgg atccattgct tcgaggacgt cacggccatc attttctgtg tcgcgctcag cggctatgac caggtgctcc acgaagacga aaccacgaac cgcatgcacg agtctctcat gctcttcgac tccatctgta acaacaagtt cttcatcgat acctccatca ttctcttcct caacaagaaa gatctctttg gcgagaagat caagaagtca cctttgacca tctgctttcc tgaatacaca ggccccaata cctatgaaga cgcagccgcc tacatccaag cacaatttga aagcaaaaac cgctcaccca acaaagaaat atattgtcac atgacttgtg ccacagacac gaataacatc caggtggtgt tcgacgccgt caccgacatc atcattgcca acaacctccg gggctgcggc ttgtactga. It is sometimes possible for the material contained within the vial of "GNAO1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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