GNA11 cdna clone
GNA11 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
Uniprot Description
G-alpha 11: a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane
Molecular Function: GTPase activity; type 2A serotonin receptor binding
Biological Process: acetylcholine receptor signaling, muscarinic pathway; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; phototransduction, visible light; platelet activation; regulation of action potential; signal transduction
Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii
Research Articles on GNA11
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Product Notes
The GNA11 gna11 (Catalog #AAA1276468) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatcgcc tgtgctgcct tcgcccgccg ccacaccggg accctgcacg gctgcttctg gcctcgacag atgacaaaag aaacagcccc aaaatacgac cactccaacc agcagttccc gcctgcctgc ccgccactgt caggcctgcc ctggcctcct cgtccgcagg gctgtctgct ggcttctggg ggcagaagag cggggagccc cgtggaaggg tcaggggaga ccaggtcagg gcagctacat ttctggtgat cagccccatg gggagacggg gctggcggga taccgccccc ccggcttccc cacaccactt ctgtctcacc cggaagcgtc ctttttttgt gccaggtgtc tacctaagag ggttggtgcc agaagccccc catggcgagt gctggggccc ggcggtgccc tgggggagca gatggggcca cccctggcag ggccgctaca actttttcca gcagcggagc cctctggggg gcctgtgctt gtggcatctc tga. It is sometimes possible for the material contained within the vial of "GNA11, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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