GGT1 cdna clone
GGT1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
Uniprot Description
GGT1: Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive. Defects in GGT1 are a cause of glutathionuria (GLUTH); also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease. Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: EC 3.4.19.13; Lipid Metabolism - arachidonic acid; Transferase; EC 2.3.2.2; Other Amino Acids Metabolism - glutathione; Membrane protein, integral; Other Amino Acids Metabolism - taurine and hypotaurine; EC 3.4.19.14; Other Amino Acids Metabolism - selenoamino acid; Other Amino Acids Metabolism - cyanoamino acid
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: anchored to external side of plasma membrane; extracellular space; plasma membrane
Molecular Function: gamma-glutamyltransferase activity; protein binding
Biological Process: amino acid metabolic process; cysteine biosynthetic process; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione metabolic process; leukotriene biosynthetic process; leukotriene metabolic process; regulation of immune system process; regulation of inflammatory response; spermatogenesis; xenobiotic metabolic process; zymogen activation
Disease: Glutathionuria
Research Articles on GGT1
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Product Notes
The GGT1 ggt1 (Catalog #AAA1278873) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgacctctg agttcttcgc tgcccagctc cgggcccaga tctctgacga caccactcac ccgatctcct actacaagcc cgagttctac acgccggatg acgggggcac tgctcacctg tctgtcgtcg cagaggacgg cagtgctgtg tccgccacca gcaccatcaa cctctacttt ggctccaagg tccgctcccc ggtcagcggg atcctgttca ataatgaaat ggacgacttc agctctccca gcatcaccaa cgagtttggg gtacccccct cacctgccaa tttcatccag ccagggaagc agccgctctc gtccatgtgc ccgacgatcg tggtgggcca ggacggccag gtccggatgg tggtgggagc tgctgggggc acacagatca ccacggccac tgcactggcc atcatctaca acctctggtt cggctatgac gtgaagcgga ccgtggagga gccccggctg cacaaccagc ttctgcccaa cgtcacgaca gtggagagaa acattgacca ggcagtgact gcagccctgg agacccggca ccatcacacc cagatcgcgt ccaccttcat cgctgtggtg caagccatcg tccgcacggc tggtggctgg gcagctgcct cggactccag gaaaggcggg gagcctgccg gctactga. It is sometimes possible for the material contained within the vial of "GGT1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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