FYCO1 cdna clone
FYCO1 cDNA Clone
Gene Names
FYCO1; CATC2; RUFY3; ZFYVE7; CTRCT18
Synonyms
FYCO1; FYCO1 cDNA Clone; FYCO1 cdna clone
Sequence
atggcctccaccaatgcagagagccagctccagagaatcatccgagacttgcaagatgctgtgacagaactaagcaaagaatttcaggaagcaggggaacccatcacggatgacagcaccagcttgcataaattttcttataaacttgagtatctcctgcaatttgatcagaaagagaaggccaccctcctgggcaacaagaaggactactgggattacttctgtgcctgcctggccaaggtgaaaggagccaatgatgggatccgctttgtcaagtctatctcagagctccgaacatccttggggaaaggaagagcatttattcgctactccttggtgcaccagaggttggcagacaccttacagcagtgcttcatgaacaccaaagtgaccagtgactggtactatgcaagaagcccctttctgcagccaaagctgagctcggacattgtgggccaactctatgagctgactgaggttcagtttgacctggcgtcgaggggctttgacttggatgctgcctggccaacatttgccaggaggacgctgaccactggctcttctgcttacctgtggaaaccccctagccgcagctccagcatgagcagcttggtgagcagctacctgcagactcaagagatggtgtccaactttgacctgaacagccccctaaacaacgaggcattggagggctttgatgagatgcgactagagctggaccagttggaggtgcgggagaagcagctacgggagcgcatgcagcagctggacagagagaaccaggagctgagggcagctgtcagccagcaaggggagcaactgcagacagagagggagagggggcgcactgcagcggaggacaacgttcgcctcacttgcttggtagctgagctccagaagcagtgggaggtcacccaggccacccagaacactgtgaaggagctgcagacatgcctgcagggcctggagctaggagcagcagagaaggaggaggactaccacacagccctgcggcggctggagtccatgctgcagcccttggcacaggagcttgaggccacacgggactcactggacaagaaaaaccagcatttagccagcttcccaggctggctagccatggctcagcagaaggcagatacggcatcagacacaaagggccggcaagaacctattcccagtgatgcggcccaggagatgcaggagctaggggagaagcttcaagccctagaaagggagagaaccaaggtcgaggaggtcaacagacagcagagtgcccaactggaacagctggtcaaggagcttcagctgaaagaggatgcccgggccagcctggagcgcctggtgaaggagatggccccactccaggaggagttgtctgggaagggacaggaggcagaccagctctggcgacggctgcaggagttgctggcccacacgagctcctgggaggaggagctagcagagttgaggcgggagaaaaaacagcaacaggaggagaaggagctgctggagcaggaggtcaggtctctgacccggcagctgcagttcctggagacccagctggcacaggtgagccaacatgtgagtgacctggaggagcagaagaagcagctcattcaggacaaagaccacctcagccagcaggtgggtatgctcgagcggcttgctgggccgcctggcccagaactgccagtggcaggtgagaagaatgaggccctggtccctgtgaactccagtctgcaagaggcctgggggaagccagaggaggagcagaggggcctgcaggaggcacagttagacgataccaaggtgcaagagggcagccaggaggaagagctccggcaggccaacagggagctggagaaggagctacagaatgtggtcgggcgtaaccagctcctggagggcaagctgcaagccctgcaggccgattaccaggctttgcagcagcgggaatcagccatccagggctccttggcctccctggaggccgagcaggccagcatccggcacttgggtgaccagatggaggcgagcttgctggctgtaaggaaggccaaggaggccatgaaagcccagatggcagagaaggaggccattctacagagcaaggagggcgagtgtcagcagctgcgggaggaggtggagcagtgccagcaactggcagaagcccggcacagagagcttagggctctcgagagccagtgccagcagcagacccagctgattgaggtcctcacagcagagaaaggccaacagggagttggcccacccactgacaatgaagcccgtgagctggctgcccagctagccctgtctcaggcgcagctggaagtccatcagggggaggtccaacggctgcaggctcaggtggtggacctccaggccaagatgcgggcagccctggatgaccaggacaaggtgcagagccagctaagcatggctgaggccgtcctgagggagcacaaaacccttgtgcagcagctgaaggagcagaatgaagcccttaacagagcccatgtccaggagctgctgcaatgctcggagcgtgaaggggcactgcaggaggagagggccgatgaggcccagcagagggaggaggagctgcgggccctgcaggaggagctgtcccaggccaaatgcagctccgaggaagcacagctggagcacgctgagctgcaagagcagctgcaccgggccaacacagacacagctgagctgggcatccaggtttgcgcactgaccgtggaaaaggagcgagtggaggaggcactggcctgtgctgtccaggagctccaggacgccaaagaggcagcctcaagggagcgagagggcctggagcgccaagtagctgggctgcagcaagagaaggagagcttgcaggagaagctgaaggcggccaaggcagcagccggctcactgcctggcctgcaggcccagctcgcccaggcagagcagcgggcccagagcctccaagaggctgcacaccaggagctcaacaccctcaagttccagctgagtgctgaaatcatggactaccagagcagacttaagaatgctggtgaagagtgcaagagcctcaggggccagcttgaggagcaaggccggcagctgcaggctgctgaggaagctgtggagaagctgaaggccacccaagcagacatgggagagaagctgagctgcactagcaaccatcttgcagagtgccaggcggccatgctgaggaaggacaaggagggggctgccctgcgtgaagacctagaaaggacccagaaggaactcgaaaaagccacaacaaaaatccaagagtattacaacaaactctgccaggaggtgacaaatcgtgagaggaatgaccagaagatgcttgctgacctggatgacctcaacagaaccaagaagtatctcgaggagcggctgatagagctgctcagggacaaggatgctctctggcagaagtcagatgccctggaattccagcagaagctcagtgctgaggagagatggctcggagacacagaggcaaaccactgcctcgactgtaagcgggagttcagctggatggtgcggcggcaccactgcaggatatgtggccgcatcttctgttactactgctgcaacaactacgtcctgagcaagcacggtggcaaaaaggagcgctgctgccgagcctgtttccagaagctcagtgaaggccctggctcccctgatagcagtggctcaggcactagccagggagagcccagccctgcactgtcaccagcctcacctgggccccaggccacaggaggccaaggagcaaatacagactacaggccaccggacgacgctgtgtttgatatcatcacagatgaggaattgtgccagatacaggagtccggctcctctttgcctgaaacacccactgaaactgattctctcgacccaaatgcggctgaacaggatactacatcaacctcgctaacgcctgaggacactgaagacatgcccgtggggcaggattcggaaatctgcctgctgaagtctggagaactgatgatcaaagtacccctcacagtggatgagatcgccagcttcggggagggtagcagggagctgtttgtgaggtccagcacctacagcctgatccccatcactgtggccgaggcaggcctcaccatcagctgggtcttctcctctgaccccaagagcatctccttcagtgtggtcttccaggaggccgaggacacaccgctggatcagtgtaaggtcctcattcccacgacccgatgcaactcccacaaggagaacatccagggccagctcaaggttcgcacacccggcatctacatgctcatcttcgacaataccttctcaaggtttgtctctaaaaaggtattttatcacttgacggttgatcggcctgtgatctacgatggaagtgatttcctgtag
Sequence Length
4437
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
168,888 Da
NCBI Official Full Name
Homo sapiens FYVE and coiled-coil domain containing 1, mRNA
NCBI Official Synonym Full Names
FYVE and coiled-coil domain containing 1
NCBI Official Symbol
FYCO1
NCBI Official Synonym Symbols
CATC2; RUFY3; ZFYVE7; CTRCT18
NCBI Protein Information
FYVE and coiled-coil domain-containing protein 1
UniProt Protein Name
FYVE and coiled-coil domain-containing protein 1
Protein Family
UniProt Gene Name
FYCO1
UniProt Synonym Gene Names
ZFYVE7
UniProt Entry Name
FYCO1_HUMAN
NCBI Description
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]
Uniprot Description
FYCO1: May mediate microtubule plus end-directed vesicle transport. Defects in FYCO1 are the cause of cataract congenital autosomal recessive type 2 (CATC2). An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Autophagy
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: autophagic vacuole; intracellular membrane-bound organelle; late endosome; lysosome; membrane
Molecular Function: protein binding
Disease: Cataract 18
Research Articles on FYCO1
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Product Notes
The FYCO1 fyco1 (Catalog #AAA1272827) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcctcca ccaatgcaga gagccagctc cagagaatca tccgagactt gcaagatgct gtgacagaac taagcaaaga atttcaggaa gcaggggaac ccatcacgga tgacagcacc agcttgcata aattttctta taaacttgag tatctcctgc aatttgatca gaaagagaag gccaccctcc tgggcaacaa gaaggactac tgggattact tctgtgcctg cctggccaag gtgaaaggag ccaatgatgg gatccgcttt gtcaagtcta tctcagagct ccgaacatcc ttggggaaag gaagagcatt tattcgctac tccttggtgc accagaggtt ggcagacacc ttacagcagt gcttcatgaa caccaaagtg accagtgact ggtactatgc aagaagcccc tttctgcagc caaagctgag ctcggacatt gtgggccaac tctatgagct gactgaggtt cagtttgacc tggcgtcgag gggctttgac ttggatgctg cctggccaac atttgccagg aggacgctga ccactggctc ttctgcttac ctgtggaaac cccctagccg cagctccagc atgagcagct tggtgagcag ctacctgcag actcaagaga tggtgtccaa ctttgacctg aacagccccc taaacaacga ggcattggag ggctttgatg agatgcgact agagctggac cagttggagg tgcgggagaa gcagctacgg gagcgcatgc agcagctgga cagagagaac caggagctga gggcagctgt cagccagcaa ggggagcaac tgcagacaga gagggagagg gggcgcactg cagcggagga caacgttcgc ctcacttgct tggtagctga gctccagaag cagtgggagg tcacccaggc cacccagaac actgtgaagg agctgcagac atgcctgcag ggcctggagc taggagcagc agagaaggag gaggactacc acacagccct gcggcggctg gagtccatgc tgcagccctt ggcacaggag cttgaggcca cacgggactc actggacaag aaaaaccagc atttagccag cttcccaggc tggctagcca tggctcagca gaaggcagat acggcatcag acacaaaggg ccggcaagaa cctattccca gtgatgcggc ccaggagatg caggagctag gggagaagct tcaagcccta gaaagggaga gaaccaaggt cgaggaggtc aacagacagc agagtgccca actggaacag ctggtcaagg agcttcagct gaaagaggat gcccgggcca gcctggagcg cctggtgaag gagatggccc cactccagga ggagttgtct gggaagggac aggaggcaga ccagctctgg cgacggctgc aggagttgct ggcccacacg agctcctggg aggaggagct agcagagttg aggcgggaga aaaaacagca acaggaggag aaggagctgc tggagcagga ggtcaggtct ctgacccggc agctgcagtt cctggagacc cagctggcac aggtgagcca acatgtgagt gacctggagg agcagaagaa gcagctcatt caggacaaag accacctcag ccagcaggtg ggtatgctcg agcggcttgc tgggccgcct ggcccagaac tgccagtggc aggtgagaag aatgaggccc tggtccctgt gaactccagt ctgcaagagg cctgggggaa gccagaggag gagcagaggg gcctgcagga ggcacagtta gacgatacca aggtgcaaga gggcagccag gaggaagagc tccggcaggc caacagggag ctggagaagg agctacagaa tgtggtcggg cgtaaccagc tcctggaggg caagctgcaa gccctgcagg ccgattacca ggctttgcag cagcgggaat cagccatcca gggctccttg gcctccctgg aggccgagca ggccagcatc cggcacttgg gtgaccagat ggaggcgagc ttgctggctg taaggaaggc caaggaggcc atgaaagccc agatggcaga gaaggaggcc attctacaga gcaaggaggg cgagtgtcag cagctgcggg aggaggtgga gcagtgccag caactggcag aagcccggca cagagagctt agggctctcg agagccagtg ccagcagcag acccagctga ttgaggtcct cacagcagag aaaggccaac agggagttgg cccacccact gacaatgaag cccgtgagct ggctgcccag ctagccctgt ctcaggcgca gctggaagtc catcaggggg aggtccaacg gctgcaggct caggtggtgg acctccaggc caagatgcgg gcagccctgg atgaccagga caaggtgcag agccagctaa gcatggctga ggccgtcctg agggagcaca aaacccttgt gcagcagctg aaggagcaga atgaagccct taacagagcc catgtccagg agctgctgca atgctcggag cgtgaagggg cactgcagga ggagagggcc gatgaggccc agcagaggga ggaggagctg cgggccctgc aggaggagct gtcccaggcc aaatgcagct ccgaggaagc acagctggag cacgctgagc tgcaagagca gctgcaccgg gccaacacag acacagctga gctgggcatc caggtttgcg cactgaccgt ggaaaaggag cgagtggagg aggcactggc ctgtgctgtc caggagctcc aggacgccaa agaggcagcc tcaagggagc gagagggcct ggagcgccaa gtagctgggc tgcagcaaga gaaggagagc ttgcaggaga agctgaaggc ggccaaggca gcagccggct cactgcctgg cctgcaggcc cagctcgccc aggcagagca gcgggcccag agcctccaag aggctgcaca ccaggagctc aacaccctca agttccagct gagtgctgaa atcatggact accagagcag acttaagaat gctggtgaag agtgcaagag cctcaggggc cagcttgagg agcaaggccg gcagctgcag gctgctgagg aagctgtgga gaagctgaag gccacccaag cagacatggg agagaagctg agctgcacta gcaaccatct tgcagagtgc caggcggcca tgctgaggaa ggacaaggag ggggctgccc tgcgtgaaga cctagaaagg acccagaagg aactcgaaaa agccacaaca aaaatccaag agtattacaa caaactctgc caggaggtga caaatcgtga gaggaatgac cagaagatgc ttgctgacct ggatgacctc aacagaacca agaagtatct cgaggagcgg ctgatagagc tgctcaggga caaggatgct ctctggcaga agtcagatgc cctggaattc cagcagaagc tcagtgctga ggagagatgg ctcggagaca cagaggcaaa ccactgcctc gactgtaagc gggagttcag ctggatggtg cggcggcacc actgcaggat atgtggccgc atcttctgtt actactgctg caacaactac gtcctgagca agcacggtgg caaaaaggag cgctgctgcc gagcctgttt ccagaagctc agtgaaggcc ctggctcccc tgatagcagt ggctcaggca ctagccaggg agagcccagc cctgcactgt caccagcctc acctgggccc caggccacag gaggccaagg agcaaataca gactacaggc caccggacga cgctgtgttt gatatcatca cagatgagga attgtgccag atacaggagt ccggctcctc tttgcctgaa acacccactg aaactgattc tctcgaccca aatgcggctg aacaggatac tacatcaacc tcgctaacgc ctgaggacac tgaagacatg cccgtggggc aggattcgga aatctgcctg ctgaagtctg gagaactgat gatcaaagta cccctcacag tggatgagat cgccagcttc ggggagggta gcagggagct gtttgtgagg tccagcacct acagcctgat ccccatcact gtggccgagg caggcctcac catcagctgg gtcttctcct ctgaccccaa gagcatctcc ttcagtgtgg tcttccagga ggccgaggac acaccgctgg atcagtgtaa ggtcctcatt cccacgaccc gatgcaactc ccacaaggag aacatccagg gccagctcaa ggttcgcaca cccggcatct acatgctcat cttcgacaat accttctcaa ggtttgtctc taaaaaggta ttttatcact tgacggttga tcggcctgtg atctacgatg gaagtgattt cctgtag. It is sometimes possible for the material contained within the vial of "FYCO1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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