FOXO4 cdna clone
FOXO4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Description
FOXO4: transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described.
Protein type: Transcription factor; Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; DNA binding; enzyme binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: cell cycle arrest; insulin receptor signaling pathway; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; stem cell differentiation; transcription from RNA polymerase II promoter
Research Articles on FOXO4
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Product Notes
The FOXO4 foxo4 (Catalog #AAA1269197) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGATCCGG GGAATGAGAA TTCAGCCACA GAGGCTGCCG CGATCATAGA CCTAGATCCC GACTTCGAAC CCCAGAGCCG TCCCCGCTCC TGCACCTGGC CCCTTCCCCG ACCAGAGATC GCTAACCAGC CGTCCGAGCC GCCCGAGGTG GAGCCAGATC TGGGGGAAAA GGTACACACG GAGGGGCGCT CAGAGCCGAT CCTGTTGCCC TCTCGGCTCC CAGAGCCGGC CGGGGGCCCC CAGCCCGGAA TCCTGGGGGC TGTAACAGGT CCTCGGAAGG GAGGCTCCCG CCGGAATGCC TGGGGAAATC AGTCATATGC AGAACTCATC AGCCAGGCCA TTGAAAGCGC CCCGGAGAAG CGACTGACAC TTGCCCAGAT CTACGAGTGG ATGGTCCGTA CTGTACCCTA CTTCAAGGAC AAGGGTGACA GCAACAGCTC AGCAGGATGG AAGAACTCGA TCCGCCACAA CCTGTCCCTG CACAGCAAGT TCATCAAGGT TCACAACGAG GCCACCGGCA AAAGCTCTTG GTGGATGCTG AACCCTGAGG GAGGCAAGAG CGGCAAAGCC CCCCGCCGCC GGGCCGCCTC CATGGATAGC AGCAGCAAGC TGCTCCGGGG CCGCAGTAAA GCCCCCAAGA AGAAACCATC TGTGCTGCCA GCTCCACCCG AAGGTGCCAC TCCAACGAGC CCTGTCGGCC ACTTTGCCAA GTGGTCAGGC AGCCCTTGCT CTCGAAACCG TGAAGAAGCC GATATGTGGA CCACCTTCCG TCCACGAAGC AGTTCAAATG CCAGCAGTGT CAGCACCCGG CTGTCCCCCT TGAGGCCAGA GTCTGAGGTG CTGGCGGAGG AAATACCAGC TTCAGTCAGC AGTTATGCAG GGGGTGTCCC TCCCACCCTC AATGAAGGTC TAGAGCTGTT AGATGGGCTC AATCTCACCT CTTCCCATTC CCTGCTATCT CGGAGTGGTC TCTCTGGCTT CTCTTTGCAG CATCCTGGGG TTACCGGCCC CTTACACACC TACAGCAGCT CCCTTTTCAG CCCAGCAGAG GGGCCCCTGT CAGCAGGAGA AGGGTGCTTC TCCAGCTCCC AGGCTCTGGA GGCCCTGCTC ACCTCTGATA CGCCACCACC CCCTGCTGAC GTCCTCATGA CCCAGGTAGA TCCCATTCTG TCCCAGGCTC CGACTCTTCT GTTGCTGGGG GGGCTTCCTT CCTCCAGTAA GCTGGCCACG GGCGTCGGCC TGTGTCCCAA GCCCCTAGAG GCTCCAGGCC CCAGCAGTCT GGTTCCCACC CTTTCTATGA TAGCACCACC TCCAGTCATG GCAAGTGCCC CCATCCCCAA GGCTCTGGGG ACTCCTGTGC TCACACCCCC TACTGAAGCT GCAAGCCAAG ACAGAATGCC TCAGGATCTA GATCTTGATA TGTATATGGA GAACCTGGAG TGTGACATGG ATAACATCAT CAGTGACCTC ATGGATGAGG GCGAGGGACT GGACTTCAAC TTTGAGCCAG ATCCCTGA. It is sometimes possible for the material contained within the vial of "FOXO4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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