FCGR2B cdna clone
FCGR2B cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Description
FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.
Protein type: Cell surface; Membrane protein, integral; Oncoprotein
Chromosomal Location of Human Ortholog: 1q23
Cellular Component: plasma membrane
Molecular Function: protein binding
Biological Process: immune response; regulation of immune response; signal transduction
Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus
Research Articles on FCGR2B
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Product Notes
The FCGR2B fcgr2b (Catalog #AAA1271516) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGGAATCC TGTCATTCTT ACCTGTCCTT GCCACTGAGA GTGACTGGGC TGACTGCAAG TCCCCCCAGC CTTGGGGTCA TATGCTTCTG TGGACAGCTG TGCTATTCCT GGCTCCTGTT GCTGGGACAC CTGCAGCTCC CCCAAAGGCT GTGCTGAAAC TCGAGCCCCA GTGGATCAAC GTGCTCCAGG AGGACTCTGT GACTCTGACA TGCCGGGGGA CTCACAGCCC TGAGAGCGAC TCCATTCAGT GGTTCCACAA TGGGAATCTC ATTCCCACCC ACACGCAGCC CAGCTACAGG TTCAAGGCCA ACAACAATGA CAGCGGGGAG TACACGTGCC AGACTGGCCA GACCAGCCTC AGCGACCCTG TGCATCTGAC TGTGCTTTCT GAGTGGCTGG TGCTCCAGAC CCCTCACCTG GAGTTCCAGG AGGGAGAAAC CATCGTGCTG AGGTGCCACA GCTGGAAGGA CAAGCCTCTG GTCAAGGTCA CATTCTTCCA GAATGGAAAA TCCAAGAAAT TTTCCCGTTC GGATCCCAAC TTCTCCATCC CACAAGCAAA CCACAGTCAC AGTGGTGATT ACCACTGCAC AGGAAACATA GGCTACACGC TGTACTCATC CAAGCCTGTG ACCATCACTG TCCAAGCTCC CAGCTCTTCA CCGATGGGGA TCATTGTGGC TGTGGTCACT GGGACTGCTG TAGCGGCCAT TGTTGCTGCT GTAGTGGCCT TGATCTACTG CAGGAAAAAG CGGATTTCAG CCAATCCCAC TAATCCTGAT GAGGCTGACA AAGTTGGGGC TGAGAACACA ATCACCTATT CACTTCTCAT GCACCCGGAT GCTCTGGAAG AGCCTGATGA CCAGAACCGT ATTTAG. It is sometimes possible for the material contained within the vial of "FCGR2B, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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