EYA3 cdna clone
EYA3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Description
EYA3: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye. Belongs to the HAD-like hydrolase superfamily. EYA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: centrosome; nucleoplasm; nucleus
Molecular Function: protein binding; protein tyrosine phosphatase activity
Biological Process: anatomical structure morphogenesis; double-strand break repair; histone dephosphorylation; positive regulation of DNA repair; response to ionizing radiation; visual perception
Research Articles on EYA3
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Product Notes
The EYA3 eya3 (Catalog #AAA1276399) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAAGAAG AGCAAGATTT ACCAGAGCAA CCAGTGAAAA AAGCCAAGAT GCAGGAATCA GGAGAGCAAA CTATAAGTCA AGTAAGCAAT CCAGATGTCA GTGATCAGAA GCCTGAAACA TCAAGCCTTG CTTCAAACCT TCCCATGTCA GAGGAAATTA TGACATGCAC CGATTACATC CCTCGCTCAT CCAATGATTA TACCTCACAA ATGTATTCTG CAAAACCTTA TGCACATATT CTCTCAGTTC CTGTTTCGGA AACTGCTTAC CCTGGACAGA CTCAATACCA GACACTACAG CAGACTCAAC CCTATGCTGT CTACCCTCAG GCAACCCAAA CGTATGGACT ACCTCCTTTT GGTGCATTGT GGCCAGGTAT GAAACCTGAA AGTGGTTTAA TTCAGACTCC ATCTCCAAGT CAACACAGTG TTCTTACCTG CACTACAGGG TTAACCACAA GCCAGCCAAG CCCAGCACAT TATTCTTATC CCATTCAAGC TTCAAGCACA AATGCCAGCC TGATATCTAC TTCTTCTACA ATTGCCAATA TTCCAGCAGC AGCAGTAGCC AGCATCTCAA ACCAGGATTA TCCCACCTAT ACTATTCTTG GTCAGAATCA GTACCAGGCC TGCTACCCCA GCTCCAGCTT TGGAGTCACA GGTCAGACTA ACAGTGATGC AGAGAGCACC ACATTAGCAG CAACCACATA CCAGTCGGAG AAGCCTAGTG TCATGGCGCC TGCACCTGCA GCACAGAGAC TTTCCTCTGG AGACCCTTCT ACAAGTCCAT CTTTGTCCCA GACTACACCA AGTAAAGATA CTGATGATCA GTCCAGGAAA AACATGACTA GCAAGAACCG GGGCAAGAGG AAAGCTGATG CCACTTCTTC CCAAGACAGT GAATTAGAAC GGGTATTTCT GTGGGACTTG GATGAAACCA TCATCATCTT CCACTCACTT CTTACTGGAT CCTATGCCCA GAAATATGGA AAGGACCCAA CAGTAGTGAT TGGCTCAGGT TTAACAATGG AAGAAATGAT TTTTGAAGTG GCTGATACTC ATCTATTTTT CAATGACTTA GAGACATAG. It is sometimes possible for the material contained within the vial of "EYA3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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