ESRRA cdna clone
ESRRA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Description
ERR1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: intercellular bridge; microtubule cytoskeleton; nucleolus; nucleoplasm; nucleus
Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; protein domain specific binding; sequence-specific DNA binding
Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter
Research Articles on ESRRA
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Product Notes
The ESRRA esrra (Catalog #AAA1271070) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCCAGCC AGGTGGTGGG CATTGAGCCT CTCTACATCA AGGCAGAGCC GGCCAGCCCT GACAGTCCAA AGGGTTCCTC GGAGACAGAG ACCGAGCCTC CTGTGGCCCT GGCCCCTGGT CCAGCTCCCA CTCGCTGCCT CCCAGGCCAC AAGGAAGAGG AGGATGGGGA GGGGGCTGGG CCTGGCGAGC AGGGCGGTGG GAAGCTGGTG CTCAGCTCCC TGCCCAAGCG CCTCTGCCTG GTCTGTGGGG ACGTGGCCTC CGGCTACCAC TATGGTGTGG CATCCTGTGA GGCCTGCAAA GCCTTCTTCA AGAGGACCAT CCAGGGGAGC ATCGAGTACA GCTGTCCGGC CTCCAACGAG TGTGAGATCA CCAAGCGGAG ACGCAAGGCC TGCCAGGCCT GCCGCTTCAC CAAGTGCCTG CGGGTGGGCA TGCTCAAGGA GGGAGTGCGC CTGGACCGCG TCCGGGGTGG GCGGCAGAAG TACAAGCGGC GGCCGGAGGT GGACCCACTG CCCTTCCCGG GCCCCTTCCC TGCTGGGCCC CTGGCAGTCG CTGGAGGCCC CCGGAAGACA GCAGCCCCAG TGAATGCACT GGTGTCTCAT CTGCTGGTGG TTGAGCCTGA GAAGCTCTAT GCCATGCCTG ACCCCGCAGG CCCTGATGGG CACCTCCCAG CCGTGGCTAC CCTCTGTGAC CTCTTTGACC GAGAGATTGT GGTCACCATC AGCTGGGCCA AGAGCATCCC AGGCTTCTCA TCGCTGTCGC TGTCTGACCA GATGTCAGTA CTGCAGAGCG TGTGGATGGA GGTGCTGGTG CTGGGTGTGG CCCAGCGCTC ACTGCCACTG CAGGATGAGC TGGCCTTCGC TGAGGACTTA GTCCTGGATG AAGAGGGGGC ACGGGCAGCT GGCCTGGGGG AACTGGGGGC TGCCCTGCTG CAACTAGTGC GGCGGCTGCA GGCCCTGCGG CTGGAGCGAG AGGAGTATGT TCTACTAAAG GCCTTGGCCC TTGCCAATTC AGACTCTGTG CACATCGAAG ATGCCGAGGC TGTGGAGCAG CTGCGAGAAG CTCTGCACGA GGCCCTGCTG GAGTATGAAG CCGGCCGGGC TGGCCCCGGA GGGGGTGCTG AGCGGCGGCG GGCGGGCAGG CTGCTGCTCA CGCTACCGCT CCTCCGCCAG ACAGCGGGCA AAGTGCTGGC CCATTTCTAT GGGGTGAAGC TGGAGGGCAA GGTGCCCATG CACAAGCTGT TCTTGGAGAT GCTCGAGGCC ATGATGGACT GA. It is sometimes possible for the material contained within the vial of "ESRRA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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