ENTPD5 cdna clone
ENTPD5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
Uniprot Description
ENTPD5: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. Belongs to the GDA1/CD39 NTPase family.
Protein type: Oncoprotein; Nucleotide Metabolism - pyrimidine; EC 3.6.1.6; Hydrolase; EC 3.6.1.42; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 14q24
Cellular Component: endoplasmic reticulum
Molecular Function: guanosine-diphosphatase activity; protein binding; uridine-diphosphatase activity
Biological Process: 'de novo' posttranslational protein folding; ATP metabolic process; cell growth; cell proliferation; positive regulation of glycolysis; protein amino acid N-linked glycosylation; regulation of phosphoinositide 3-kinase cascade
Research Articles on ENTPD5
Similar Products
Product Notes
The ENTPD5 entpd5 (Catalog #AAA1275394) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccactt cttggggcac agtctttttc atgctggtgg tatcctgtgt ttgcagcgct gtctcccaca ggaaccagca gacttggttt gagggtatct tcctgtcttc catgtgcccc atcaatgtca gcgccagcac cttgtatgga attatgtttg atgcagggag cactggaact cgaattcatg tttacacctt tgtgcagaaa atgccaggac agcttccaat tctagaaggg gaagtttttg attctgtgaa gccaggactt tctgcttttg tagatcaacc taagcagggt gctgagaccg ttcaagggct cttagaggtg gccaaagact caatcccccg aagtcactgg aaaaagaccc cagtggtcct aaaggcaaca gcaggactac gcttactgcc agaacacaaa gccaaggctc tgctctttga ggtaaaggag atcttcagga agtcaccttt cctggtacca aagggcagtg ttagcatcat ggatggatcc gacgaaggca tattagcttg ggttactgtg aattttctga caggtcagct gcatggccac agacaggaga ctgtggggac cttggaccta gggggagcct ccacccaaat cacgttcctg ccccagtttg agaaaactct ggaacaaact cctaggggct acctcacttc ctttgagatg tttaacagca cttataagct ctatacacat agttacctgg gatttggatt gaaagctgca agactagcaa ccctgggagc cctggagaca gaagggactg atgggcacac tttccggagt gcctgtttac cgagatggtt ggaagcagag tggatctttg ggggtgtgaa ataccagtat ggtggcaacc aagaagggga ggtgggcttt gagccctgct atgccgaagt gctgagggtg gtacgaggaa aacttcacca gccagaggag gtccagagag gttccttcta tgctttctct tactattatg accgagctgt tgacacagac atgattgatt atgaaaaggg gggtatttta aaagttgaag attttgaaag aaaagccagg gaagtgtgtg ataacttgga aaacttcacc tcaggcagtc ctttcctgtg catggatctc agctacatca cagccctgtt aaaggatggc tttggctttg cagacagcac agtcttacag ctcacaaaga aagtgaacaa catagagacg ggctgggcct tgggggccac ctttcacctg ttgcagtctc tgggcatctc ccattga. It is sometimes possible for the material contained within the vial of "ENTPD5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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