DTX3 cdna clone

DTX3 cDNA Clone

Cat. Num. AAA1267312

• Gene Names: DTX3; RNF154; deltex3
• Synonyms: DTX3; DTX3 cDNA Clone; DTX3 cdna clone

• Sequence: ATGTCGTTCGTCCTGTCCAGAATGGCAGCCTGTGGAGGCACCTGCAAGAACAAAGTGACTGTGTCCAAGCCCGTGTGGGACTTCCTGAGCAAAGAGACCCCAGCCCGGCTGGCCCGGCTTCGGGAGGAGCACCGTGTGTCCATCCTCATAGATGGCGAGACTTCTGACATCTATGTTCTCCAGCTTTCCCCACAGGGTCCTCCCCCGGCCCCTCCAAATGGGCTCTACCTAGCCCGGAAGGCTCTCAAGGGGCTGCTAAAAGAGGCAGAGAAAGAGCTGAAGAAAGCTCAGAGGCAGGGGGAGCTGATGGGCTGCCTGGCTCTGGGGGGTGGAGGGGAGCACCCTGAGATGCACCGCGCAGGCCCACCCCCTCTCCGAGCAGCCCCACTTCTGCCCCCAGGAGCTCGGGGGCTCCCCCCTCCTCCTCCCCCCCTGCCCCCACCTCTTCCTCCTCGCCTTCGGGAGGAGGCAGAAGAGCAGGAGAGCACCTGCCCCATCTGTCTGGGGGAGATCCAGAATGCCAAGACATTGGAGAAGTGCCGGCATTCATTCTGCGAGGGCTGCATCACCCGGGCTCTGCAGGTGAAAAAGGCCTGCCCCATGTGCGGCCGCTTCTATGGGCAGCTGGTGGGCAACCAGCCCCAGAATGGGCGGATGCTGGTCTCTAAGGACGCCACCCTCCTACTGCCCAGCTATGAGAAGTACGGCACCATTGTCATCCAGTACGTCTTCCCGCCCGGTGTCCAGGGGGCTGAACACCCAAACCCAGGAGTTCGGTATCCTGGCACCACACGGGTGGCCTACCTCCCGGACTGCCCTGAGGGCAACAAGGTGCTGACCCTGTTCCGCAAGGCGTTTGACCAGCGTCTCACCTTCACTATCGGCACGTCCATGACCACAGGGAGACCGAATGTCATCACCTGGAACGACATCCACCACAAGACCAGCTGCACAGGGGGACCCCAGCTGTTTGGGTACCCAGACCCCACCTACCTGACCCGGGTGCAAGAGGAGCTGAGAGCGAAGGGTATCACAGATGACTGA
• Sequence Length: 1044

• Vector: Please Inquire

NCBI and Uniprot Product Information

• NCBI GI #: 109730338
• NCBI GeneID: 196403
• Molecular Weight: 38,155 Da
• NCBI Official Full Name: Homo sapiens deltex homolog 3 (Drosophila), mRNA
• NCBI Official Synonym Full Names: deltex E3 ubiquitin ligase 3
• NCBI Official Symbol: DTX3
• NCBI Official Synonym Symbols: RNF154; deltex3
• NCBI Protein Information: probable E3 ubiquitin-protein ligase DTX3
• UniProt Protein Name: Probable E3 ubiquitin-protein ligase DTX3
• Protein Family: Protein DETOXIFICATION
• UniProt Gene Name: DTX3
• UniProt Synonym Gene Names: RNF154; Deltex3
• UniProt Entry Name: DTX3_HUMAN

NCBI Description

DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

Uniprot Description

DTX3: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 12q13.3

Molecular Function: protein binding