Sequence
ATGGCATCTCTGAGCCAGCTGAGTAGCCACCTGAACTACACCTGTGGGGCAGAGAACTCCACAGGTGCCAGCCAGGCCCGCCCACATGCCTACTATGCCCTCTCCTACTGCGCGCTCATCCTGGCCATCGTCTTCGGCAATGGCCTGGTGTGCATGGCTGTGCTGAAGGAGCGGGCCCTGCAGACTACCACCAACTACTTAGTAGTGAGCCTGGCTGTGGCAGACTTGCTGGTGGCCACCTTGGTGATGCCCTGGGTGGTATACCTGGAGGTGACAGGTGGAGTCTGGAATTTCAGCCACATTTGCTGTGATGTTTTTGTCACCCTGGATGTCATGATGTGTACAGCCAGCATCCTTAATCTCTGTGCCATCAGCATAGACAGGTACACTGCAGTGGTCATGCCCGTTCACTACCAGCATGGCACGGGACAGAGCTCCTGTCGGCGCGTGGCCCTCATGATCACGGCCGTCTGGGTACTGGCCTTTGCTGTGTCCTGCCCTCTTCTGTTTGGCTTTAATACCACAGGGGACCCCACTGTCTGCTCCATCTCCAACCCTGATTTTGTCATCTACTCTTCAGTGGTGTCCTTCTACCTGCCCTTTGGAGTGACTGTCCTTGTCTATGCCAGAATCTATGAGGTGCTGAAACAAAGGAGACGGAAAAGGATCCTCACTCGACAGAACAGTCAGTGCAACAGTGTCAGGCCTGGCTTCCCCCAACAAACCCTCTCTCCTGACCCGGCACATCTGGAGCTGAAGCGTTACTACAGCATCTGCCAGGACACTGCCTTGGGTGGACCAGGCTTCCAAGAAAGAGGAGGAGAGTTGAAAAGAGAGGAGAAGACTCGGAATTCCCTGAGTCCCACCATAGCGCCCAAGCTCAGCTTAGAAGTTCGAAAACTCAGCAATGGCAGATTATCGACATCTTTGAAGCTGGGGCCCCCGCAACCTCGGGGAGTGCCACTTCGGGAGAAGAAGGCAACCCAAATGGTGGCCATTGTGCTTGGGGCCTTCATTGTCTGCTGGCTGCCCTTCTTCTTGACCCATGTTCTCAATACCCACTGCCAGACATGCCACGTGTCCCCAGAGCTTTACAGTGCCACGACATGGCTGGGCTACGTGAATAGCGCCCTCAACCCTGTGATCTATACCACCTTCAATATCGAGTTCCGGAAAGCCTTCCTCAAGATCCTGTCTTGCTGA
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
Molecular Weight
40,760 Da
NCBI Official Full Name
Homo sapiens dopamine receptor D3, mRNA
NCBI Official Synonym Full Names
dopamine receptor D3
NCBI Official Symbol
DRD3
NCBI Official Synonym Symbols
D3DR; ETM1; FET1
NCBI Protein Information
D(3) dopamine receptor
UniProt Protein Name
D(3) dopamine receptor
UniProt Entry Name
DRD3_HUMAN
NCBI Description
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Uniprot Description
DRD3: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 3q13.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; drug binding; protein binding
Biological Process: acid secretion; arachidonic acid secretion; behavioral response to cocaine; cellular calcium ion homeostasis; circadian regulation of gene expression; dopamine metabolic process; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; locomotory behavior; musculoskeletal movement, spinal reflex action; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; positive regulation of cytokinesis; positive regulation of dopamine receptor signaling pathway; positive regulation of mitosis; prepulse inhibition; regulation of cAMP metabolic process; regulation of dopamine secretion; regulation of dopamine uptake; response to cocaine; response to drug; response to ethanol; response to morphine; synaptic transmission, dopaminergic; visual learning
Disease: Schizophrenia; Tremor, Hereditary Essential, 1
Research Articles on DRD3
Similar Products
Product Notes
The DRD3 drd3 (Catalog #
AAA1274612) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCATCTC TGAGCCAGCT GAGTAGCCAC CTGAACTACA CCTGTGGGGC AGAGAACTCC ACAGGTGCCA GCCAGGCCCG CCCACATGCC TACTATGCCC TCTCCTACTG CGCGCTCATC CTGGCCATCG TCTTCGGCAA TGGCCTGGTG TGCATGGCTG TGCTGAAGGA GCGGGCCCTG CAGACTACCA CCAACTACTT AGTAGTGAGC CTGGCTGTGG CAGACTTGCT GGTGGCCACC TTGGTGATGC CCTGGGTGGT ATACCTGGAG GTGACAGGTG GAGTCTGGAA TTTCAGCCAC ATTTGCTGTG ATGTTTTTGT CACCCTGGAT GTCATGATGT GTACAGCCAG CATCCTTAAT CTCTGTGCCA TCAGCATAGA CAGGTACACT GCAGTGGTCA TGCCCGTTCA CTACCAGCAT GGCACGGGAC AGAGCTCCTG TCGGCGCGTG GCCCTCATGA TCACGGCCGT CTGGGTACTG GCCTTTGCTG TGTCCTGCCC TCTTCTGTTT GGCTTTAATA CCACAGGGGA CCCCACTGTC TGCTCCATCT CCAACCCTGA TTTTGTCATC TACTCTTCAG TGGTGTCCTT CTACCTGCCC TTTGGAGTGA CTGTCCTTGT CTATGCCAGA ATCTATGAGG TGCTGAAACA AAGGAGACGG AAAAGGATCC TCACTCGACA GAACAGTCAG TGCAACAGTG TCAGGCCTGG CTTCCCCCAA CAAACCCTCT CTCCTGACCC GGCACATCTG GAGCTGAAGC GTTACTACAG CATCTGCCAG GACACTGCCT TGGGTGGACC AGGCTTCCAA GAAAGAGGAG GAGAGTTGAA AAGAGAGGAG AAGACTCGGA ATTCCCTGAG TCCCACCATA GCGCCCAAGC TCAGCTTAGA AGTTCGAAAA CTCAGCAATG GCAGATTATC GACATCTTTG AAGCTGGGGC CCCCGCAACC TCGGGGAGTG CCACTTCGGG AGAAGAAGGC AACCCAAATG GTGGCCATTG TGCTTGGGGC CTTCATTGTC TGCTGGCTGC CCTTCTTCTT GACCCATGTT CTCAATACCC ACTGCCAGAC ATGCCACGTG TCCCCAGAGC TTTACAGTGC CACGACATGG CTGGGCTACG TGAATAGCGC CCTCAACCCT GTGATCTATA CCACCTTCAA TATCGAGTTC CGGAAAGCCT TCCTCAAGAT CCTGTCTTGC TGA.
It is sometimes possible for the material contained within the vial of
"DRD3, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
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