DOCK8 cdna clone
DOCK8 cDNA Clone
Gene Names
DOCK8; MRD2; ZIR8; HEL-205
Synonyms
DOCK8; DOCK8 cDNA Clone; DOCK8 cdna clone
Sequence
atgacacacctgaacagcctggatgtgcagcttgcccaggagctcggggacttcactgatgacgacttggacgtggtgttcacgccaaaggaatgtaggactttgcagccctctttgccggaggaaggggttgaactggaccctcatgtcagggactgtgttcagacctacatccgtgagtggctaatcgtgaaccggaaaaaccaaggaagtccagaaatctgtggctttaaaaagactggatctcgaaaagattttcacaagacgcttccgaaacagacgtttgagtcggaaaccttggagtgcagtgaacccgctgctcaggcaggcccccgccacttaaacgtgctgtgcgacgtgtctgggaaaggccccgtcactgcctgtgactttgacctccgcagcctgcagcctgacaagcggctagaaaacctcctgcagcaagtgagtgccgaggactttgagaagcagaacgaggaggcccggaggaccaataggcaggccgagctctttgccctttacccatcagtggacgaggaggatgctgtggaaatacgtccagtaccagaatgtcccaaggaacacctgggcaacagaatattggtcaagttgctgaccttgaagttcgagattgaaattgagcccctgtttgccagcattgccctctacgatgttaaagaaaggaaaaagatctcagaaaattttcactgtgacctgaactctgaccagttcaaaggatttctgcgagctcacacgccttcagtggccgcatcaagtcaggcgagatctgcagtcttctcagtcacctacccgtcctcagacatctacctggtagtcaagattgaaaaagtcctgcagcagggagagattggagactgtgcagagccctacacggttatcaaagaaagtgatggtggaaagagtaaagaaaagattgaaaaactaaaactccaagctgaatccttctgccagcgtttggggaaataccggatgccctttgcctgggcacccataagcttatcaagcttcttcagtgtctccacccttgagagggaggtaactgatgtggactctgtggttgggagaagctcagtgggtgaacggaggacattggcccaatctagaaggctttctgaaagagccctctccttggaggaaaatggggttggatccaacttcaaaacctccactctgagcgttagcatctttttcaagcaggaaggagatcgccttagcgatgaagacttattcaagtttttagctgactacaaaagatcatcatccttacagagacgagtcaagtcaattccaggcttgctaagactggagatttctacagctccagagatcatcaattgctgtctgactcctgaaatgctgcccgtgaaaccctttcctgaaaaccggacacgcccgcacaaagagattttggaatttccaacacgagaagtatatgtccctcacactgtgtacagaaaccttctctatgtctacccacagaggctgaactttgtaaacaaactagcatcagcccggaacattacaataaagatccagtttatgtgtggagaagatgctagcaatgcgatgccggtcatctttggaaagtccagcgggcctgaatttctgcaggaagtgtacacagctgttacataccataataagtctcctgacttttatgaagaagtgaaaattaagctccccgctaagctcacagtaaatcaccacctcctgttcaccttctaccatatcagctgtcagcagaagcaaggagcctccgtggaaactctcctgggatattcatggctgccaattctcttaaatgaacgtcttcaaactggatcctactgtctcccagttgccttggaaaaattgccacccaactactccatgcattctgctgagaaagtcccattacagaatcctcccattaagtgggctgaaggacataagggagtatttaatattgaagtgcaagctgtttcttctgtacacacccaggacaaccacctggagaagttcttcaccctctgccactccctggagagccaggtgaccttccccatccgcgtgctggatcagaaaatcagcgagatggcgctggagcatgagctgaagctcagcatcatctgcctcaactcctcccgcctggagccgctcgtgctcttcctgcacctggtgctggacaagctcttccagctgtccgtgcagcccatggtcatcgctggccagacagccaacttctcccagtttgccttcgagtccgtggtggccatcgccaacagtctgcacaacagcaaggacctgagcaaggaccagcatgggaggaactgcctgctggcttcctacgtgcactacgtcttccgcctgccagaggtgcaaagggatgtgcccaagtcaggcgctcccactgccctcctagaccctcggagctaccacacgtatggccgcacatcagctgctgctgtgagttcaaagctgctgcaggcccgggtgatgagcagcagtaacccagacctcgcggggacacactccgcagcagacgaggaagtgaagaacatcatgtcttcaaagcatttccatgaggagcttgcccttcagatggtggtcagcactggaatggtgagagaaacagtcttcaagtatgcctggttcttctttgagcttctggtgaaaagcatggcccagcacgtacataacatggacaaacgggacagttttcggaggactcgtttttctgaccgtttcatggatgacataactactattgttaatgtggtcacctcggaaattgcagcccttttagtaaaaccacagaaggaaaatgaacaggcggaaaagatgaacatcagcctggctttcttcttgtatgaccttctctccctcatggatcggggctttgtgtttaacctcatcagacattattgcagccagctgtcagccaagctcagtaaccttccaacgctcatttccatgaggctagagttcctgagaatcctctgtagccatgagcattacctcaatctgaaccttttttttatgaatgctgatactgctccaacatctccttgtccttccatatcttcccagaactcaagctcctgctccagcttccaggaccagaagatcgccagcatgttcgatctgacttccgagtaccgccagcagcacttcctcaccgggctcctcttcacagaactggctgctgccctggatgccgaaggggaaggaatcagcaaagtacaaaggaaagctgtcagtgcaattcacagcctgctaagttctcacgacctggacccacgctgtgtcaaaccagaggtgaaggtcaaaatcgccgccctttacctacctttagttggcatcattttggatgctttgccacagctctgtgactttacagttgcagatactcgcagataccgcaccagtggctcggatgaagaacaagaaggagccggtgccattaaccagaatgtggctctggccatagcagggaataatttcaatttgaaaacaagtggaatagtgctgtcttccttgccctataagcagtacaacatgctgaacgcggacactactcgcaacctcatgatctgcttcctctggatcatgaaaaatgctgatcagagcctcattaggaagtggattgctgacctgccatcaacgcagctcaacaggattttagatctacttttcatctgtgtgttatgttttgagtataagggaaaacagagttctgacaaagtcagtacccaagtcctgcagaagtcaagggatgtcaaggcccggctggaagaggctttgctccgtggggaaggggccagaggggagatgatgcgccgccgggctccagggaacgaccgatttccaggcctaaatgaaaatttgagatggaagaaagagcagacacattggcggcaagctaatgagaagctagataaaacaaaggccgagttagatcaagaagccttgatcagtggcaatctggctacagaagcacatttaatcatcctggatatgcaggaaaacattatccaggcgagctcggctctggactgtaaagacagcctgctgggaggtgttctgagggtgctggtgaattctctgaactgtgatcagagtaccacctacctgactcactgctttgcaacactccgtgctctcatcgccaagtttggagacttactcttcgaagaggaggtggaacagtgtttcgacctatgtcaccaagtcctgcaccactgcagcagcagcatggatgtcacccggagccaagcctgtgccaccctttacctcctcatgaggttcagttttggagccaccagtaattttgcaagagtaaagatgcaagtaaccatgtccctggcatctttggtgggaagagcaccagactttaatgaagagcacctgagaagatccttgaggacaattttggcctattcagaagaggacacagccatgcagatgactccttttcccacccaggtggaggaacttctctgtaatctgaatagcatcttatatgacacagtgaaaatgagggaatttcaggaagatcctgagatgcttatggatctcatgtacagaattgccaagagttaccaggcatctcctgatctgcggctgacctggctccagaacatggcagagaaacacaccaagaagaagtgctacacggaggctgccatgtgcctggtgcacgccgctgcgttagtggctgagtatctgagcatgctggaggaccacagctacctgcccgtgggcagtgtcagcttccagaatatttcttccaatgtgctggaggagtctgtggtctctgaggacaccctgtcacctgacgaggatggggtgtgcgcaggccagtacttcaccgagagtggcctggtaggcctcctggagcaggccgcggagctcttcagcacgggaggcttatatgagacagttaatgaggtctacaagctggtcatccccatcctagaagcgcatcgagaattccggaagctgacactcactcacagcaagctgcagagagccttcgacagcatcgttaacaaggatcataagagaatgtttggaacctacttccgagttggtttctttggatccaaatttggggatttggatgaacaggaatttgtctacaaagagcctgcaattaccaagcttcctgagatctcacatagactagaggcattttatggtcaatgttttggtgcagaatttgtggaagtgattaaagactccactcctgtggacaaaaccaagttggatcctaacaaggcctacatacagatcacttttgtggagccctactttgatgagtatgagatgaaagacagggtcacatactttgagaagaatttcaacctccggaggttcatgtacaccaccccgttcaccctggaggggcggcctcggggagagctgcatgagcagtacagaaggaacacagtcctgaccactatgcacgccttccccttcatcaagaccaggatcagcgtcatccagaaggaggagtttgttttgacaccgattgaagttgccattgaagacatgaagaagaagaccctgcagttagcagttgccattaaccaggagccgcctgatgcaaagatgcttcagatggtgctgcaaggctctgtgggagctactgtaaatcagggaccactggaagtagcccaagtgtttttggctgaaattcctgctgatccaaaactctatcgacatcacaacaagttgaggttatgctttaaggaattcatcatgagatgtggtgaagctgtagagaaaaacaagcgtctcatcacggcagaccagagggaatatcagcaggaactcaaaaagaactataacaagctaaaagagaacctcaggccaatgatcgagcggaaaattccagaactgtacaagccaatattcagagttgagagtcaaaagagggactccttccacagatctagtttcaggaaatgtgaaacccagttgtcacagggcagctaa
Sequence Length
6000
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
227,477 Da
NCBI Official Full Name
Homo sapiens dedicator of cytokinesis 8, mRNA
NCBI Official Synonym Full Names
dedicator of cytokinesis 8
NCBI Official Symbol
DOCK8
NCBI Official Synonym Symbols
MRD2; ZIR8; HEL-205
NCBI Protein Information
dedicator of cytokinesis protein 8
UniProt Protein Name
Dedicator of cytokinesis protein 8
Protein Family
UniProt Gene Name
DOCK8
UniProt Entry Name
DOCK8_HUMAN
NCBI Description
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
Uniprot Description
DOCK8: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; GEFs, misc.; GEFs
Chromosomal Location of Human Ortholog: 9p24.3
Cellular Component: cytosol; membrane
Molecular Function: protein binding
Biological Process: blood coagulation
Disease: Hyper-ige Recurrent Infection Syndrome, Autosomal Recessive; Mental Retardation, Autosomal Dominant 2
Research Articles on DOCK8
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Product Notes
The DOCK8 dock8 (Catalog #AAA1273711) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgacacacc tgaacagcct ggatgtgcag cttgcccagg agctcgggga cttcactgat gacgacttgg acgtggtgtt cacgccaaag gaatgtagga ctttgcagcc ctctttgccg gaggaagggg ttgaactgga ccctcatgtc agggactgtg ttcagaccta catccgtgag tggctaatcg tgaaccggaa aaaccaagga agtccagaaa tctgtggctt taaaaagact ggatctcgaa aagattttca caagacgctt ccgaaacaga cgtttgagtc ggaaaccttg gagtgcagtg aacccgctgc tcaggcaggc ccccgccact taaacgtgct gtgcgacgtg tctgggaaag gccccgtcac tgcctgtgac tttgacctcc gcagcctgca gcctgacaag cggctagaaa acctcctgca gcaagtgagt gccgaggact ttgagaagca gaacgaggag gcccggagga ccaataggca ggccgagctc tttgcccttt acccatcagt ggacgaggag gatgctgtgg aaatacgtcc agtaccagaa tgtcccaagg aacacctggg caacagaata ttggtcaagt tgctgacctt gaagttcgag attgaaattg agcccctgtt tgccagcatt gccctctacg atgttaaaga aaggaaaaag atctcagaaa attttcactg tgacctgaac tctgaccagt tcaaaggatt tctgcgagct cacacgcctt cagtggccgc atcaagtcag gcgagatctg cagtcttctc agtcacctac ccgtcctcag acatctacct ggtagtcaag attgaaaaag tcctgcagca gggagagatt ggagactgtg cagagcccta cacggttatc aaagaaagtg atggtggaaa gagtaaagaa aagattgaaa aactaaaact ccaagctgaa tccttctgcc agcgtttggg gaaataccgg atgccctttg cctgggcacc cataagctta tcaagcttct tcagtgtctc cacccttgag agggaggtaa ctgatgtgga ctctgtggtt gggagaagct cagtgggtga acggaggaca ttggcccaat ctagaaggct ttctgaaaga gccctctcct tggaggaaaa tggggttgga tccaacttca aaacctccac tctgagcgtt agcatctttt tcaagcagga aggagatcgc cttagcgatg aagacttatt caagttttta gctgactaca aaagatcatc atccttacag agacgagtca agtcaattcc aggcttgcta agactggaga tttctacagc tccagagatc atcaattgct gtctgactcc tgaaatgctg cccgtgaaac cctttcctga aaaccggaca cgcccgcaca aagagatttt ggaatttcca acacgagaag tatatgtccc tcacactgtg tacagaaacc ttctctatgt ctacccacag aggctgaact ttgtaaacaa actagcatca gcccggaaca ttacaataaa gatccagttt atgtgtggag aagatgctag caatgcgatg ccggtcatct ttggaaagtc cagcgggcct gaatttctgc aggaagtgta cacagctgtt acataccata ataagtctcc tgacttttat gaagaagtga aaattaagct ccccgctaag ctcacagtaa atcaccacct cctgttcacc ttctaccata tcagctgtca gcagaagcaa ggagcctccg tggaaactct cctgggatat tcatggctgc caattctctt aaatgaacgt cttcaaactg gatcctactg tctcccagtt gccttggaaa aattgccacc caactactcc atgcattctg ctgagaaagt cccattacag aatcctccca ttaagtgggc tgaaggacat aagggagtat ttaatattga agtgcaagct gtttcttctg tacacaccca ggacaaccac ctggagaagt tcttcaccct ctgccactcc ctggagagcc aggtgacctt ccccatccgc gtgctggatc agaaaatcag cgagatggcg ctggagcatg agctgaagct cagcatcatc tgcctcaact cctcccgcct ggagccgctc gtgctcttcc tgcacctggt gctggacaag ctcttccagc tgtccgtgca gcccatggtc atcgctggcc agacagccaa cttctcccag tttgccttcg agtccgtggt ggccatcgcc aacagtctgc acaacagcaa ggacctgagc aaggaccagc atgggaggaa ctgcctgctg gcttcctacg tgcactacgt cttccgcctg ccagaggtgc aaagggatgt gcccaagtca ggcgctccca ctgccctcct agaccctcgg agctaccaca cgtatggccg cacatcagct gctgctgtga gttcaaagct gctgcaggcc cgggtgatga gcagcagtaa cccagacctc gcggggacac actccgcagc agacgaggaa gtgaagaaca tcatgtcttc aaagcatttc catgaggagc ttgcccttca gatggtggtc agcactggaa tggtgagaga aacagtcttc aagtatgcct ggttcttctt tgagcttctg gtgaaaagca tggcccagca cgtacataac atggacaaac gggacagttt tcggaggact cgtttttctg accgtttcat ggatgacata actactattg ttaatgtggt cacctcggaa attgcagccc ttttagtaaa accacagaag gaaaatgaac aggcggaaaa gatgaacatc agcctggctt tcttcttgta tgaccttctc tccctcatgg atcggggctt tgtgtttaac ctcatcagac attattgcag ccagctgtca gccaagctca gtaaccttcc aacgctcatt tccatgaggc tagagttcct gagaatcctc tgtagccatg agcattacct caatctgaac ctttttttta tgaatgctga tactgctcca acatctcctt gtccttccat atcttcccag aactcaagct cctgctccag cttccaggac cagaagatcg ccagcatgtt cgatctgact tccgagtacc gccagcagca cttcctcacc gggctcctct tcacagaact ggctgctgcc ctggatgccg aaggggaagg aatcagcaaa gtacaaagga aagctgtcag tgcaattcac agcctgctaa gttctcacga cctggaccca cgctgtgtca aaccagaggt gaaggtcaaa atcgccgccc tttacctacc tttagttggc atcattttgg atgctttgcc acagctctgt gactttacag ttgcagatac tcgcagatac cgcaccagtg gctcggatga agaacaagaa ggagccggtg ccattaacca gaatgtggct ctggccatag cagggaataa tttcaatttg aaaacaagtg gaatagtgct gtcttccttg ccctataagc agtacaacat gctgaacgcg gacactactc gcaacctcat gatctgcttc ctctggatca tgaaaaatgc tgatcagagc ctcattagga agtggattgc tgacctgcca tcaacgcagc tcaacaggat tttagatcta cttttcatct gtgtgttatg ttttgagtat aagggaaaac agagttctga caaagtcagt acccaagtcc tgcagaagtc aagggatgtc aaggcccggc tggaagaggc tttgctccgt ggggaagggg ccagagggga gatgatgcgc cgccgggctc cagggaacga ccgatttcca ggcctaaatg aaaatttgag atggaagaaa gagcagacac attggcggca agctaatgag aagctagata aaacaaaggc cgagttagat caagaagcct tgatcagtgg caatctggct acagaagcac atttaatcat cctggatatg caggaaaaca ttatccaggc gagctcggct ctggactgta aagacagcct gctgggaggt gttctgaggg tgctggtgaa ttctctgaac tgtgatcaga gtaccaccta cctgactcac tgctttgcaa cactccgtgc tctcatcgcc aagtttggag acttactctt cgaagaggag gtggaacagt gtttcgacct atgtcaccaa gtcctgcacc actgcagcag cagcatggat gtcacccgga gccaagcctg tgccaccctt tacctcctca tgaggttcag ttttggagcc accagtaatt ttgcaagagt aaagatgcaa gtaaccatgt ccctggcatc tttggtggga agagcaccag actttaatga agagcacctg agaagatcct tgaggacaat tttggcctat tcagaagagg acacagccat gcagatgact ccttttccca cccaggtgga ggaacttctc tgtaatctga atagcatctt atatgacaca gtgaaaatga gggaatttca ggaagatcct gagatgctta tggatctcat gtacagaatt gccaagagtt accaggcatc tcctgatctg cggctgacct ggctccagaa catggcagag aaacacacca agaagaagtg ctacacggag gctgccatgt gcctggtgca cgccgctgcg ttagtggctg agtatctgag catgctggag gaccacagct acctgcccgt gggcagtgtc agcttccaga atatttcttc caatgtgctg gaggagtctg tggtctctga ggacaccctg tcacctgacg aggatggggt gtgcgcaggc cagtacttca ccgagagtgg cctggtaggc ctcctggagc aggccgcgga gctcttcagc acgggaggct tatatgagac agttaatgag gtctacaagc tggtcatccc catcctagaa gcgcatcgag aattccggaa gctgacactc actcacagca agctgcagag agccttcgac agcatcgtta acaaggatca taagagaatg tttggaacct acttccgagt tggtttcttt ggatccaaat ttggggattt ggatgaacag gaatttgtct acaaagagcc tgcaattacc aagcttcctg agatctcaca tagactagag gcattttatg gtcaatgttt tggtgcagaa tttgtggaag tgattaaaga ctccactcct gtggacaaaa ccaagttgga tcctaacaag gcctacatac agatcacttt tgtggagccc tactttgatg agtatgagat gaaagacagg gtcacatact ttgagaagaa tttcaacctc cggaggttca tgtacaccac cccgttcacc ctggaggggc ggcctcgggg agagctgcat gagcagtaca gaaggaacac agtcctgacc actatgcacg ccttcccctt catcaagacc aggatcagcg tcatccagaa ggaggagttt gttttgacac cgattgaagt tgccattgaa gacatgaaga agaagaccct gcagttagca gttgccatta accaggagcc gcctgatgca aagatgcttc agatggtgct gcaaggctct gtgggagcta ctgtaaatca gggaccactg gaagtagccc aagtgttttt ggctgaaatt cctgctgatc caaaactcta tcgacatcac aacaagttga ggttatgctt taaggaattc atcatgagat gtggtgaagc tgtagagaaa aacaagcgtc tcatcacggc agaccagagg gaatatcagc aggaactcaa aaagaactat aacaagctaa aagagaacct caggccaatg atcgagcgga aaattccaga actgtacaag ccaatattca gagttgagag tcaaaagagg gactccttcc acagatctag tttcaggaaa tgtgaaaccc agttgtcaca gggcagctaa. It is sometimes possible for the material contained within the vial of "DOCK8, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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