DKK3 cdna clone
DKK3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Description
DKK3: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: extracellular space
Biological Process: adrenal gland development; anatomical structure morphogenesis; negative regulation of aldosterone biosynthetic process; negative regulation of transcription, DNA-dependent
Research Articles on DKK3
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Product Notes
The DKK3 dkk3 (Catalog #AAA1277044) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcagcggc ttggggccac cctgctgtgc ctgctgctgg cggcggcggt ccccacggcc cccgcgcccg ctccgacggc gacctcggct ccagtcaagc ccggcccggc tctcagctac ccgcaggagg aggccaccct caatgagatg ttccgcgagg ttgaggaact gatggaggac acgcagcaca aattgcgcag cgcggtggaa gagatggagg cagaagaagc tgctgctaaa gcatcatcag aagtgaacct ggcaaactta cctcccagct atcacaatga gaccaacaca gacacgaagg ttggaaataa taccatccat gtgcaccgag aaattcacaa gataaccaac aaccagactg gacaaatggt cttttcagag acagttatca catctgtggg agacgaagaa ggcagaagga gccacgagtg catcatcgac gaggactgtg ggcccagcat gtactgccag tttgccagct tccagtacac ctgccagcca tgccggggcc agaggatgct ctgcacccgg gacagtgagt gctgtggaga ccagctgtgt gtctggggtc actgcaccaa aatggccacc aggggcagca atgggaccat ctgtgacaac cagagggact gccagccggg gctgtgctgt gccttccaga gaggcctgct gttccctgtg tgcacacccc tgcccgtgga gggcgagctt tgccatgacc ccgccagccg gcttctggac ctcatcacct gggagctaga gcctgatgga gccttggacc gatgcccttg tgccagtggc ctcctctgcc agccccacag ccacagcctg gtgtatgtgt gcaagccgac cttcgtgggg agccgtgacc aagatgggga gatcctgctg cccagagagg tccccgatga gtatgaagtt ggcagcttca tggaggaggt gcgccaggag ctggaggacc tggagaggag cctgactgaa gagatggcgc tgggggagcc tgcggctgcc gccgctgcac tgctgggagg ggaagagatt tag. It is sometimes possible for the material contained within the vial of "DKK3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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