DISP1 cdna clone
DISP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Uniprot Description
DISP1: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Belongs to the dispatched family.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q41
Molecular Function: peptide transporter activity; protein binding
Biological Process: peptide transport; smoothened signaling pathway
Research Articles on DISP1
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Product Notes
The DISP1 disp1 (Catalog #AAA1267379) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctatga gcaatggaaa caatgatttt gtggttctga gcaacagcag catcgcaacc agtgctgcta acccgagtcc cctcaccccc tgtgatggag accatgcagc ccagcagctc acacccaaag aagcaacaag aacaaaagtg agtccaaatg gatgcctgca acttaatggc acggtcaaat catcctttct gcctttagac aaccaaagaa tgcctcagat gttaccccaa tgctgccatc cttgcccata ccatcaccct ttgactagcc atagcagtca ccaagagtgc catcccgagg ctggccctgc agcaccctct gctttggcct cgtgttgcat gcagccacac tccgagtatt ctgcatctct ttgtccaaat cattcacctg tgtatcagac tacgtgctgt cttcagccct ctccatcctt ctgcctgcat catccgtggc ctgaccattt tcagcatcag cctgtgcaac agcacatagc caacataaga ccatccagac ctttcaagtt gccaaaaagt tatgcagccc tgatagccga ctggccggtg gtggtcttgg gcatgtgcac catgttcatc gtagtctgtg ccttggttgg agtattagtg ccagagctcc ctgacttctc tgatccattg ctgggttttg aaccaagagg aacagcaata ggccagagat tggtcacatg gaataatatg gtgaaaaata caggatacaa agcaacatta gcaaattatc cctttaaata tgcagatgaa caagccaaaa gccatcggga tgatagatgg tcagatgatc attatgaaag agagaaaaga gaagttgact ggaacttcca caaggacagc tttttctgcg acgttccaag tgaccgatat tccagagtgg tatttacttc atctggaggg gagacattat ggaatttacc tgcaattaaa tcaatgtgca atgtagataa ttccaggatc agatctcatc cccagtttgg tgatctctgc cagaggacca ctgctgcctc ctgctgcccc agctggacac tgggaaacta catcgccatt ctgaacaata gatcgtcctg tcagaaaata gttgagcgag acgtttctca taccttgaag ctgcttcgga cttgtgccaa acactaccaa aatggcactc tggggccaga ctgctgggac atggcagcca gaagaaagga ccagctcaag tgcaccaatg tgccacgcaa atgtaccaag tacaatgctg tgtaccagat cctccattac ttggtggaca aagactttat gaccccaaag acggctgact atgccacgcc agctttaaaa tacagcatgc tcttctctcc cacagagaaa ggggagagca tgatgaacat ttacttggac aactttgaaa actggaactc ttctgacggc gtgactacca tcaccgggat tgagtttggt atcaaacaca gtttgtttca ggattatctt ctaatggata ctgtgtatcc tgccatagcc attgtgattg tccttttagt tatgtgtgtc tacaccaagt ccatgtttat cactctgatg acaatgtttg caataatcag ttctttgatt gtttcctaa. It is sometimes possible for the material contained within the vial of "DISP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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