DHX58 cdna clone
DHX58 cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
DHX58: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. Belongs to the helicase family. RLR subfamily.
Protein type: Helicase; EC 3.6.4.13; Inhibitor
Chromosomal Location of Human Ortholog: 17q21.2
Molecular Function: double-stranded RNA binding; protein binding; single-stranded RNA binding; zinc ion binding
Biological Process: negative regulation of innate immune response; negative regulation of interferon type I production; positive regulation of interferon type I production; regulation of innate immune response; response to virus
Research Articles on DHX58
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Product Notes
The DHX58 dhx58 (Catalog #AAA1272633) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagcttc ggtcctacca atgggaggtg atcatgcctg ccctggaggg caagaatatc atcatctggc tgcccacggg tgccgggaag acccgggcgg ctgcttatgt ggccaagcgg cacctagaga ctgtggatgg agccaaggtg gttgtattgg tcaacagggt gcacctggtg acccagcatg gtgaagagtt caggcgcatg ctggatggac gctggaccgt gacaaccctg agtggggaca tgggaccacg tgctggcttt ggccacctgg cccggtgcca tgacctgctc atctgcacag cagagcttct gcagatggca ctgaccagcc ccgaggagga ggagcacgtg gagctcactg tcttctccct gatcgtggtg gatgagtgcc accacacgca caaggacacc gtctacaacg tcatcatgag ccagtaccta gaacttaaac tccagagggc acagccgcta ccccaggtgc tgggtctcac agcctcccca ggcactggcg gggcctccaa actcgatggg gccatcaacc acgtcctgca gctctgtgcc aacttggaca cgtggtgcat catgtcaccc cagaactgct gcccccagct gcaggagcac agccaacagc cttgcaaaca gtacaacctc tgccacaggc gcagccagga tccgtttggg gacttgctga agaagctcat ggaccaaatc catgaccacc tggagatgcc tgagttgagc cggaaatttg ggacgcaaat gtatgagcag caggtggtga agctgagtga ggctgcggct ttggctgggc ttcaggagca acgggtgtat gcgcttcacc tgaggcgcta caatgacgcg ctgctcatcc atgacaccgt ccgcgccgtg gatgccttgg ctgcgctgca ggatttctat cacagggagc acgtcactaa aacccagatc ctgtgtgccg agcgccggct gctggccctg ttcgatgacc gcaagaatga gctggcccac ttggcaactc atggcccaga gaatccaaaa ctggagatgc tggaaaagat cctgcaaagg cagttcagta gctctaacag ccctcggggt atcatcttca cccgcacccg ccaaagcgca cactccctcc tgctctggct ccagcagcag cagggcctgc agactgtgga catccgggcc cagctactga ttggggctgg gaacagcagc cagagcaccc acatgaccca gagggaccag caagaagtga tccagaagtt ccaagatgga accctgaacc ttctggtggc cacgagtgtg gcggaggagg ggctggacat cccacattgc aatgtggtgg tgcgttatgg gctcttgacc aatgaaatct ccatggtcca ggccaggggc cgtgcccggg ccgatcagag tgtatacgcg tttgtagcaa ctgaaggtag ccgggagctg aagcgggagc tgatcaacga ggcgctggag acgctgatgg agcaggcagt ggctgctgtg cagaaaatgg accaggccga gtaccaggcc aagatccggg atctgcagca ggcagccttg accaagcggg cggcccaggc agcccagcgg gagaaccagc ggcagcagtt cccagtggag cacgtgcagc tactctgcat caactgcatg gtggctgtgg gccatggcag cgacctgcgg aaggtggagg gcacccacca tgtcaatgtg aaccccaact tctcgaacta ctataatgtc tccagggatc ctgtggtcat caacaaagtc ttcaaggact ggaagcctgg gggtgtcatc agctgcagga actgtgggga ggtctggggt ctgcagatga tctacaagtc agtgaagctg ccagtgctca aagtccgcag catgctgctg gagacccctc aggggcggat ccaggccaaa aagtggtccc gcgtgccctt ctccgtgcct gactttgact tcctgcagca ttgtgccgag aacttgtcgg acctctccct ggactga. It is sometimes possible for the material contained within the vial of "DHX58, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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