DAB1 cdna clone
DAB1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: intracellular membrane-bound organelle; microtubule organizing center; nucleolus
Molecular Function: protein binding
Research Articles on DAB1
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Product Notes
The DAB1 dab1 (Catalog #AAA1278578) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCAACTG AGACAGAACT TCAAGTAGCT GTGAAAACCA GCACCAAGAA AGACTCCAGA AAGAAAGGTC AGGATCGCAG TGAAGCCACT TTGATAAAGA GGTTTAAAGG TGAAGGGGTC CGGTACAAAG CCAAATTGAT CGGGATTGAT GAAGTTTCCG CAGCTCGGGG AGACAAGTTA TGTCAAGATT CCATGATGAA ACTCAAGGGC GTTGTTGCTG GCGCTCGTTC CAAAGGAGAA CACAAACAGA AAATCTTTTT AACCATCTCC TTTGGAGGAA TCAAAATCTT TGATGAGAAG ACAGGGGCCC TTCAGCATCA TCATGCTGTT CATGAAATAT CCTACATTGC AAAGGACATT ACAGATCACC GGGCCTTTGG ATATGTTTGT GGGAAGGAAG GGAATCACAG ATTTGTGGCC ATAAAAACAG CCCAGGCGGC TGAACCTGTT ATTCTGGACT TGAGAGATCT CTTTCAACTC ATTTATGAAT TGAAGCAAAG AGAAGAATTA GAAAAAAAGG CACAAAAGGA TAAGCAGTGT GAACAAGCTG TGTACCAGGT TCCCACCAGC CAAAAGAAGG AAGGTGTTTA TGATGTGCCA AAAAGTCAAC CTGTAAGTAA TGGCTATTCG TTTGAGGATT TTGAAGAACG GTTTGCTGCA GCCACCCCGG CTGTGACCCA ATTAGAACTT TTTGGGGACA TGTCCACACC CCCTGATATA ACCTCTCCCC CCACTCCTGC AACTCCAGGT GATGCCTTTA TCCCATCTTC ATCTCAGACC CTTCCAGCGA GTGCAGATGT GTTTAGTTCT GTACCTTTCG GCACTGCTGC TGTACCCTCA GGTTACGTTG CAATGGGCGC TGTCCTCCCG TCCTTCTGGG GTCAGCAGCC CCTCGTCCAA CAGCAGATGG TCATGGGTGC CCAGCCACCA GTCGCTCAGG TGATGCCGGG GGCTCAGCCC ATCGCATGGG GCCAGCCGGG TCTCTTTCCT GCCACTCAGC AGCCCTGGCC AACTGTGGCC GGGCAGTTTC CGCCAGCCGC CTTCATGCCC ACACAAACTG TTATGCCTTT GCCAGCTGCC ATGTTCCAAG GTCCCCTCAC CCCCCTTGCC ACCGTCCCAG GCACGAGTGA CTCCACCAGG TCAAGTCCAC AGACCGACAA GCCCAGGCAG AAAATGGGCA AAGAAACGTT TAAGGATTTC CAGATGGCCC AGCCTCCGCC CGTGCCCTCC CGCAAACCCG ACCAGCCCTC CCTCACCTGT ACCTCAGAGG CCTTCTCCAG TTACTTCAAC AAAGTCGGGG TGGCACAGGA TACAGACGAC TGTGATGACT TTGACATCTC CCAGTTGAAT TTGACCCCTG TGACTTCTAC CACACCATCG ACCAACTCAC CTCCAACCCC AGCCCCTAGA CAGAGCTCTC CATCCAAATC ATCTGCATCC CATGCCAGTG ATCCTACCAC AGATGACATC TTTGAAGAGG GCTTTGAAAG TCCCAGCAAA AGCGAAGAGC AAGAAGCTCC TGATGGATCA CAGGCCTCAT CCAACAGTGA TCCATTTGGT GAGCCCAGTG GGGAGCCCAG TGGTGATAAT ATAAGTCCAC AGGCCGGTAG CTAG. It is sometimes possible for the material contained within the vial of "DAB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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