CTSL1 cdna clone
CTSL1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Description
CTSL1: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.
Protein type: EC 3.4.22.15; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 9q21.33
Cellular Component: extracellular region; extracellular space; lysosomal lumen; lysosome; nucleus
Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; histone binding; protein binding; proteoglycan binding; serine-type endopeptidase activity
Biological Process: adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; collagen catabolic process; extracellular matrix disassembly; proteolysis; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway
Research Articles on CTSL1
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Product Notes
The CTSL1 ctsl (Catalog #AAA1270566) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaatccta cactcatcct tgctgccttt tgcctgggaa ttgcctcagc tactctaaca tttgatcaca gtttagaggc acagtggacc aagtggaagg cgatgcacaa cagattatac ggcatgaatg aagaaggatg gaggagagca gtgtgggaga agaacgtgaa gatgattgaa ctgcacaatc aggaatacag ggaagggaaa cacagcttca caatggccat gaacgccttt ggagacatga ccagtgaaga attcaggcag gtgatgaatg gctttcaaaa ccgtaagccc aggaagggga aagtgttcca ggaacctctg ttttatgagg cccccagatc tgtggattgg agagagaaag gctacgtgac tcctgtgaag aatcagggtc agtgtggttc ttgttgggct tttagtgcta ctggtgctct tgaaggacag atgttccgga aaactgggag gcttatctca ctgagtgagc agaatctggt agactgctct gggcctcaag gcaatgaagg ctgcaatggt ggcctaatgg attatgcttt ccagtatgtt caggataatg gaggcctgga ctctgaggaa tcctatccat atgaggcaac agaagaatcc tgtaagtaca atcccaagta ttctgttgct aatgacaccg gctttgtgga catccctaag caggagaagg ccctgatgaa ggcagttgca actgtggggc ccatttctgt tgctattgat gcaggtcatg agtccttcct gttctataaa gaaggcattt attttgagcc agactgtagc agtgaagaca tggatcatgg tgtgctggtg gttggctacg gatttgaaag cacagaatca gataacaata aatattggct ggtgaagaac agctggggtg aagaatgggg catgggtggc tacgtaaaga tggccaaaga ccggagaaac cattgtggaa ttgcctcagc agccagctac cccactgtgt ga. It is sometimes possible for the material contained within the vial of "CTSL1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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