CRYBB1 cdna clone
CRYBB1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]
Uniprot Description
CRYBB1: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization. The protease responsible for this partial degradation could be calpain II.
Chromosomal Location of Human Ortholog: 22q12.1
Molecular Function: protein binding
Disease: Cataract 17, Multiple Types
Research Articles on CRYBB1
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Product Notes
The CRYBB1 crybb1 (Catalog #AAA1269781) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctcagg ctgcaaaggc ctcggcctcg gccacagtgg cggtgaaccc agggcctgac accaagggga agggggcccc acctgcagga acatccccta gtcccggcac taccctggcc ccaacaaccg tgcctattac cagcgccaag gcggcggaac tgcctcctgg gaactacagg ctggtggtct tcgaactgga aaacttccag ggccgtcgag cagaattctc gggggagtgc tcaaatctgg cagaccgtgg cttcgaccgt gtgcgcagca tcattgtctc cgcgggaccc tgggtcgcct ttgagcagtc caacttccgc ggggagatgt tcatcctgga gaagggcgag taccctcgct ggaacacatg gtcgagcagc taccgcagtg atcggctcat gtccttccgg cccatcaaaa tggatgccca ggagcacaaa atctccctgt ttgaaggggc caacttcaag ggcaacacca tagagatcca gggggacgac gcacccagtc tctgggtcta cggcttcagt gaccgcgtgg gcagcgtgaa ggtctccagt ggaacatggg ttggctatca gtatcctggc taccgcgggt accagtacct cctagagcct ggtgacttcc ggcactggaa tgagtgggga gccttccagc cacagatgca gtccctgcgt cgcctgcgtg acaagcagtg gcacctcgag gggtccttcc ctgtcctggc cacagagccc cccaagtga. It is sometimes possible for the material contained within the vial of "CRYBB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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