CREB3 cdna clone
CREB3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Uniprot Description
CREB3: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: endoplasmic reticulum; nucleus
Molecular Function: protein binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response
Research Articles on CREB3
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Product Notes
The CREB3 creb3 (Catalog #AAA1268247) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagctgg aattggatgc tggtgaccaa gacctgctgg ccttcctgct agaggaaagt ggagatttgg ggacggcacc cgatgaggcc gtgagggccc cactggactg ggcgctgccg ctttctgagg taccgagcga ctgggaagta gatgatttgc tgtgctccct gctgagtccc ccagcgtcgt tgaacattct cagctcctcc aacccctgcc ttgtccacca tgaccacacc tactccctcc cacgggaaac tgtctctatg gatctagaga gtgagagctg tagaaaagag gggacccaga tgactccaca gcatatggag gagctggcag agcaggagat tgctaggcta gtactgacag atgaggagaa gagtctattg gagaaggagg ggcttattct gcctgagaca cttcctctca ctaagacaga ggaacaaatt ctgaaacgtg tgcggaggaa gattcgaaat aaaagatctg ctcaagagag ccgcaggaaa aagaaggtgt atgttggggg tttagagagc agggtcttga aatacacagc ccagaatatg gagcttcaga acaaagtaca gcttctggag gaacagaatt tgtcccttct agatcaactg aggaaactcc aggccatggt gattgagata tcaaacaaaa ccagcagcag cagcacctgc atcttggtcc tactagtctc cttctgcctc ctccttgtac ctgctattta ctcctctgac acaaggggga gcctgccagc tgagcatgga gtgttgtccc gccagcttcg tgccctcccc agtgaggacc cttaccagct ggagctgcct gccctgcagt cagaagtgcc gaaagacagc acacaccagt ggttggacgg ctcagactgt gtactccagg cccctggcaa cacttcctgc ctgctgcatt acatgcctca ggctcccagt gcagagcctc ccctggagtg gccattccct gacctcttct cagagcctct ctgccgaggt cccatcctcc ccctgcaggc aaatctcaca aggaagggag gatggcttcc tactggtagc ccctctgtca ttttgcagga cagatactca ggctag. It is sometimes possible for the material contained within the vial of "CREB3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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