CDC16 cdna clone
CDC16 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
Uniprot Description
CDC16: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. Belongs to the APC6/CDC16 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: anaphase-promoting complex; centrosome; cytoplasm; cytosol; nucleoplasm; spindle; spindle microtubule
Molecular Function: protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of mitosis; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Research Articles on CDC16
Similar Products
Product Notes
The CDC16 cdc16 (Catalog #AAA1272656) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggaagagc ccatcaataa aagattattt gaaaaatact tgaaggacga aagtggcttc aaagatcctt ccagcgactg ggaaatgtca cagtcttcaa taaagagttc tatctgtctt ctacgcggga aaatctatga tgctctagat aaccgaaccc tggctaccta cagctacaaa gaagctttga agcttgatgt ctactgtttt gaagcgttcg atcttttaac atcacatcac atgctgacag cacaagaaga aaaagaactt cttgaatcac taccccttag caagctgtgt aatgaagaac aggaattgct gcgttttcta tttgagaaca aattgaaaaa atataataag cctagtgaaa cggtcatccc tgaatctgta gatggcttgc aagagaatct ggatgtggta gtgtctttag ctgagagaca ttattataac tgtgatttta aaatgtgcta caagcttact tctgtagtaa tggagaaaga tcctttccat gcaagttgtt tacctgtaca tatagggacg cttgtagagc tgaataaagc caatgaactt ttctatcttt ctcataaact ggtggattta tatcctagta atcctgtgtc ttggtttgca gtgggatgtt actatctcat ggtcggtcat aaaaatgaac atgccagaag atatctcagc aaagccacaa cacttgagaa aacctatgga cctgcatgga tagcctatgg acattcattt gcggtggaga gtgagcacga ccaagcgatg gctgcttact tcacagcagc acagctgatg aaagggtgtc atttgcctat gctgtatatt ggattagaat atggtttgac caataactca aaactagctg aaaggttctt cagccaagct ctgagcattg caccggaaga cccttttgtt atgcatgagg tcggcgtggt tgcatttcag aatggagaat ggaaaacagc cgaaaaatgg tttcttgatg ctttggaaaa aattaaagca attgggaacg aggtaacagt tgacaaatgg gaacctttgt tgaacaactt ggggcatgtc tgcagaaaac ttaaaaagta tgctgaggcc ttggattacc accgtcaggc actggtgttg attcctcaga acgcatccac ctactctgct attggatata tccacagtct gatgggcaac tttgaaaatg ctgtggacta cttccacaca gcccttggtc ttaggcgaga tgatacattt tctgttacaa tgcttggtca ttgcatcgaa atgtacattg gtgattctga agcttatatt ggagcagaca ttaaagacaa attaaaatgt tatgactttg atgtgcatac aatgaagaca ctaaaaaaca ttatttcacc tccgtgggat ttcagggaat ttgaagtaga aaaacagact gcagaagaaa cggggcttac gccattggaa acctcaagga aaactccaga ttccagacct tccttggaag aaacctttga aattgaaatg aatgaaagtg acatgatgtt agagacatct atgtcagacc acagcacgtg a. It is sometimes possible for the material contained within the vial of "CDC16, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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