CCT2 cdna clone
CCT2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Description
CCT2: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: chaperonin-containing T-complex; cytoplasm; cytosol; extracellular matrix; microtubule
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: chaperone cofactor-independent protein folding; chaperone-mediated protein complex assembly; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein folding; protein stabilization
Research Articles on CCT2
Similar Products
Product Notes
The CCT2 cct2 (Catalog #AAA1274673) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcgtccc tttcccttgc acctgttaac atctttaagg caggagctga tgaagagaga gcagagacag ctcgtctgac ttcttttatt ggtgccatcg ccattggaga cttggtaaag agcaccttgg gacccaaagg catggacaaa attcttctaa gcagtggacg agatgcctct cttatggtaa ccaatgatgg tgccactatt ctaaaaaaca ttggtgttga caatccagca gctaaagttt tagttgatat gtcaagggtt caagatgatg aagttggtga tggcactacc tctgttaccg ttttagcagc agaattatta agggaagcag aatctttaat tgcaaaaaag attcatccac agaccatcat agcgggttgg agagaagcca cgaaggctgc aagagaggcg ctgttgagtt ctgcagttga tcatggttcc gatgaagtta aattccgtca agatttaatg aatattgcgg gcacaacatt atcctcaaaa cttcttactc atcacaaaga ccactttaca aagttagctg tagaagcagt tctcagactg aaaggctctg gcaacctgga ggcaattcat attatcaaga agctaggagg aagtttggca gattcctatt tagatgaagg cttcctgttg gataaaaaaa ttggagtaaa tcaaccaaaa cgaattgaaa atgctaaaat tcttattgca aatactggta tggatacaga caaaataaag atatttggtt cccgggtaag agttgactct acggcaaagg ttgcagaaat agaacatgcg gaaaaggaaa aaatgaagga gaaagttgaa cgtattctta agcatggaat aaattgcttt attaacaggc aattaattta taattatcct gaacagctct ttggtgctgc tggtgtcatg gctattgagc atgcagattt tgcaggtgtg gaacgcctag ctcttgtcac aggtggtgaa attgcctcta cctttgatca cccagaactg gtgaagcttg gaagttgcaa acttatcgag gaagtcatga ttggagaaga caaactcatt cacttttctg gggttgccct tggtgaggct tgtaccattg ttttgcgtgg tgccactcaa caaattttag atgaagcaga aagatcattg catgatgctc tttgtgttct tgcgcaaact gtaaaggact ctagaacagt ttatggagga ggctgttctg agatgttgat ggctcatgct gtgacacagc ttgccaatag aacaccaggc aaagaagctg ttgcaatgga gtcttatgct aaagcactga gaatgttgcc aaccatcata gctgacaatg caggctatga cagtgcagac ctggtggcac agctcagggc tgctcacagt gaaggcaata ccactgctgg attggatatg agggaaggca ccattggaga tatggctatc ctgggtataa cagaaagttt tcaagtgaag cgacaggttc ttctgagtgc agctgaagca gcagaggtga ttctgcgtgt ggacaacatc atcaaagcgg cacccaggaa acgtgtccct gatcaccacc cctgttaa. It is sometimes possible for the material contained within the vial of "CCT2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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