CASR cdna clone
CASR cDNA Clone
Gene Names
CASR; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
Synonyms
CASR; CASR cDNA Clone; CASR cdna clone
Sequence
ATGGCATTTTATAGCTGCTGCTGGGTCCTCTTGGCACTCACCTGGCACACCTCTGCCTACGGGCCAGACCAGCGAGCCCAAAAGAAGGGGGACATTATCCTTGGGGGGCTCTTTCCTATTCATTTTGGAGTAGCAGCTAAAGATCAAGATCTCAAATCAAGGCCGGAGTCTGTGGAATGTATCAGGTATAATTTCCGTGGGTTTCGCTGGTTACAGGCTATGATATTTGCCATAGAGGAGATAAACAGCAGCCCAGCCCTTCTTCCCAACTTGACGCTGGGATACAGGATATTTGACACTTGCAACACCGTTTCTAAGGCCTTGGAAGCCACCCTGAGTTTTGTTGCTCAAAACAAAATTGATTCTTTGAACCTTGATGAGTTCTGCAACTGCTCAGAGCACATTCCCTCTACGATTGCTGTGGTGGGAGCAACTGGCTCAGGCGTCTCCACGGCAGTGGCAAATCTGCTGGGGCTCTTCTACATTCCCCAGGTCAGTTATGCCTCCTCCAGCAGACTCCTCAGCAACAAGAATCAATTCAAGTCTTTCCTCCGAACCATCCCCAATGATGAGCACCAGGCCACTGCCATGGCAGACATCATCGAGTATTTCCGCTGGAACTGGGTGGGCACAATTGCAGCTGATGACGACTATGGGCGGCCGGGGATTGAGAAATTCCGAGAGGAAGCTGAGGAAAGGGATATCTGCATCGACTTCAGTGAACTCATCTCCCAGTACTCTGATGAGGAAGAGATCCAGCATGTGGTAGAGGTGATTCAAAATTCCACGGCCAAAGTCATCGTGGTTTTCTCCAGTGGCCCAGATCTTGAGCCCCTCATCAAGGAGATTGTCCGGCGCAATATCACGGGCAAGATCTGGCTGGCCAGCGAGGCCTGGGCCAGCTCCTCCCTGATCGCCATGCCTCAGTACTTCCACGTGGTTGGCGGCACCATTGGATTCGCTCTGAAGGCTGGGCAGATCCCAGGCTTCCGGGAATTCCTGAAGAAGGTCCATCCCAGGAAGTCTGTCCACAATGGTTTTGCCAAGGAGTTTTGGGAAGAAACATTTAACTGCCACCTCCAAGAAGGTGCAAAAGGACCTTTACCTGTGGACACCTTTCTGAGAGGTCACGAAGAAAGTGGCGACAGGTTTAGCAACAGCTCGACAGCCTTCCGACCCCTCTGTACAGGGGATGAGAACATCAGCAGTGTCGAGACCCCTTACATAGATTACACGCATTTACGGATATCCTACAATGTGTACTTAGCAGTCTACTCCATTGCCCACGCCTTGCAAGATATATATACCTGCTTACCTGGGAGAGGGCTCTTCACCAATGGCTCCTGTGCAGACATCAAGAAAGTTGAGGCGTGGCAGGTCCTGAAGCACCTACGGCATCTAAACTTTACAAACAATATGGGGGAGCAGGTGACCTTTGATGAGTGTGGTGACCTGGTGGGGAACTATTCCATCATCAACTGGCACCTCTCCCCAGAGGATGGCTCCATCGTGTTTAAGGAAGTCGGGTATTACAACGTCTATGCCAAGAAGGGAGAAAGACTCTTCATCAACGAGGAGAAAATCCTGTGGAGTGGGTTCTCCAGGGAGGTGCCCTTCTCCAACTGCAGCCGAGACTGCCTGGCAGGGACCAGGAAAGGGATCATTGAGGGGGAGCCCACCTGCTGCTTTGAGTGTGTGGAGTGTCCTGATGGGGAGTATAGTGATGAGACAGATGCCAGTGCCTGTAACAAGTGCCCAGATGACTTCTGGTCCAATGAGAACCACACCTCCTGCATTGCCAAGGAGATCGAGTTTCTGTCGTGGACGGAGCCCTTTGGGATCGCACTCACCCTCTTTGCCGTGCTGGGCATTTTCCTGACAGCCTTTGTGCTGGGTGTGTTTATCAAGTTCCGCAACACACCCATTGTCAAGGCCACCAACCGAGAGCTCTCCTACCTCCTCCTCTTCTCCCTGCTCTGCTGCTTCTCCAGCTCCCTGTTCTTCATCGGGGAGCCCCAGGACTGGACGTGCCGCCTGCGCCAGCCGGCCTTTGGCATCAGCTTCGTGCTCTGCATCTCATGCATCCTGGTGAAAACCAACCGTGTCCTCCTGGTGTTTGAGGCCAAGATCCCCACCAGCTTCCACCGCAAGTGGTGGGGGCTCAACCTGCAGTTCCTGCTGGTTTTCCTCTGCACCTTCATGCAGATTGTCATCTGTGTGATCTGGCTCTACACCGCGCCCCCCTCAAGCTACCGCAACCAGGAGCTGGAGGATGAGATCATCTTCATCACGTGCCACGAGGGCTCCCTCATGGCCCTGGGCTTCCTGATCGGCTACACCTGCCTGCTGGCTGCCATCTGCTTCTTCTTTGCCTTCAAGTCCCGGAAGCTGCCGGAGAACTTCAATGAAGCCAAGTTCATCACCTTCAGCATGCTCATCTTCTTCATCGTCTGGATCTCCTTCATTCCAGCCTATGCCAGCACCTATGGCAAGTTTGTCTCTGCCGTAGAGGTGATTGCCATCCTGGCAGCCAGCTTTGGCTTGCTGGCGTGCATCTTCTTCAACAAGATCTACATCATTCTCTTCAAGCCATCCCGCAACACCATCGAGGAGGTGCGTTGCAGCACCGCAGCTCACGCTTTCAAGGTGGCTGCCCGGGCCACGCTGCGCCGCAGCAACGTCTCCCGCAAGCGGTCCAGCAGCCTTGGAGGCTCCACGGGATCCACCCCCTCCTCCTCCATCAGCAGCAAGAGCAACAGCGAAGACCCATTCCCACAGCCCGAGAGGCAGAAGCAGCAGCAGCCGCTGGCCCTAACCCAGCAAGAGCAGCAGCAGCAGCCCCTGACCCTCCCACAGCAGCAACGATCTCAGCAGCAGCCCAGATGCAAGCAGAAGGTCATCTTTGGCAGCGGCACGGTCACCTTCTCACTGAGCTTTGATGAGCCTCAGAAGAACGCCATGGCCCACAGGAATTCTACGCACCAGAACTCCCTGGAGGCCCAGAAAAGCAGCGATACGCTGACCCGACACCAGCCATTACTCCCGCTGCAGTGCGGGGAAACGGACTTAGATCTGACCGTCCAGGAAACAGGTCTGCAAGGACCTGTGGGTGGAGACCAGCGGCCAGAGGTGGAGGACCCTGAAGAGTTGTCCCCAGCACTTGTAGTGTCCAGTTCACAGAGCTTTGTCATCAGTGGTGGAGGCAGCACTGTTACAGAAAACGTAGTGAATTCATAA
Sequence Length
3237
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
121,772 Da
NCBI Official Full Name
Homo sapiens calcium-sensing receptor, mRNA
NCBI Official Synonym Full Names
calcium sensing receptor
NCBI Official Symbol
CASR
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
NCBI Protein Information
extracellular calcium-sensing receptor
UniProt Protein Name
Extracellular calcium-sensing receptor
Protein Family
UniProt Gene Name
CASR
UniProt Synonym Gene Names
GPRC2A; PCAR1; CaSR; PCaR1
UniProt Entry Name
CASR_HUMAN
NCBI Description
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
Uniprot Description
CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 3; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q13
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: phosphoinositide phospholipase C activity; protein binding
Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; ossification
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I
Research Articles on CASR
Similar Products
Product Notes
The CASR casr (Catalog #AAA1271481) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCATTTT ATAGCTGCTG CTGGGTCCTC TTGGCACTCA CCTGGCACAC CTCTGCCTAC GGGCCAGACC AGCGAGCCCA AAAGAAGGGG GACATTATCC TTGGGGGGCT CTTTCCTATT CATTTTGGAG TAGCAGCTAA AGATCAAGAT CTCAAATCAA GGCCGGAGTC TGTGGAATGT ATCAGGTATA ATTTCCGTGG GTTTCGCTGG TTACAGGCTA TGATATTTGC CATAGAGGAG ATAAACAGCA GCCCAGCCCT TCTTCCCAAC TTGACGCTGG GATACAGGAT ATTTGACACT TGCAACACCG TTTCTAAGGC CTTGGAAGCC ACCCTGAGTT TTGTTGCTCA AAACAAAATT GATTCTTTGA ACCTTGATGA GTTCTGCAAC TGCTCAGAGC ACATTCCCTC TACGATTGCT GTGGTGGGAG CAACTGGCTC AGGCGTCTCC ACGGCAGTGG CAAATCTGCT GGGGCTCTTC TACATTCCCC AGGTCAGTTA TGCCTCCTCC AGCAGACTCC TCAGCAACAA GAATCAATTC AAGTCTTTCC TCCGAACCAT CCCCAATGAT GAGCACCAGG CCACTGCCAT GGCAGACATC ATCGAGTATT TCCGCTGGAA CTGGGTGGGC ACAATTGCAG CTGATGACGA CTATGGGCGG CCGGGGATTG AGAAATTCCG AGAGGAAGCT GAGGAAAGGG ATATCTGCAT CGACTTCAGT GAACTCATCT CCCAGTACTC TGATGAGGAA GAGATCCAGC ATGTGGTAGA GGTGATTCAA AATTCCACGG CCAAAGTCAT CGTGGTTTTC TCCAGTGGCC CAGATCTTGA GCCCCTCATC AAGGAGATTG TCCGGCGCAA TATCACGGGC AAGATCTGGC TGGCCAGCGA GGCCTGGGCC AGCTCCTCCC TGATCGCCAT GCCTCAGTAC TTCCACGTGG TTGGCGGCAC CATTGGATTC GCTCTGAAGG CTGGGCAGAT CCCAGGCTTC CGGGAATTCC TGAAGAAGGT CCATCCCAGG AAGTCTGTCC ACAATGGTTT TGCCAAGGAG TTTTGGGAAG AAACATTTAA CTGCCACCTC CAAGAAGGTG CAAAAGGACC TTTACCTGTG GACACCTTTC TGAGAGGTCA CGAAGAAAGT GGCGACAGGT TTAGCAACAG CTCGACAGCC TTCCGACCCC TCTGTACAGG GGATGAGAAC ATCAGCAGTG TCGAGACCCC TTACATAGAT TACACGCATT TACGGATATC CTACAATGTG TACTTAGCAG TCTACTCCAT TGCCCACGCC TTGCAAGATA TATATACCTG CTTACCTGGG AGAGGGCTCT TCACCAATGG CTCCTGTGCA GACATCAAGA AAGTTGAGGC GTGGCAGGTC CTGAAGCACC TACGGCATCT AAACTTTACA AACAATATGG GGGAGCAGGT GACCTTTGAT GAGTGTGGTG ACCTGGTGGG GAACTATTCC ATCATCAACT GGCACCTCTC CCCAGAGGAT GGCTCCATCG TGTTTAAGGA AGTCGGGTAT TACAACGTCT ATGCCAAGAA GGGAGAAAGA CTCTTCATCA ACGAGGAGAA AATCCTGTGG AGTGGGTTCT CCAGGGAGGT GCCCTTCTCC AACTGCAGCC GAGACTGCCT GGCAGGGACC AGGAAAGGGA TCATTGAGGG GGAGCCCACC TGCTGCTTTG AGTGTGTGGA GTGTCCTGAT GGGGAGTATA GTGATGAGAC AGATGCCAGT GCCTGTAACA AGTGCCCAGA TGACTTCTGG TCCAATGAGA ACCACACCTC CTGCATTGCC AAGGAGATCG AGTTTCTGTC GTGGACGGAG CCCTTTGGGA TCGCACTCAC CCTCTTTGCC GTGCTGGGCA TTTTCCTGAC AGCCTTTGTG CTGGGTGTGT TTATCAAGTT CCGCAACACA CCCATTGTCA AGGCCACCAA CCGAGAGCTC TCCTACCTCC TCCTCTTCTC CCTGCTCTGC TGCTTCTCCA GCTCCCTGTT CTTCATCGGG GAGCCCCAGG ACTGGACGTG CCGCCTGCGC CAGCCGGCCT TTGGCATCAG CTTCGTGCTC TGCATCTCAT GCATCCTGGT GAAAACCAAC CGTGTCCTCC TGGTGTTTGA GGCCAAGATC CCCACCAGCT TCCACCGCAA GTGGTGGGGG CTCAACCTGC AGTTCCTGCT GGTTTTCCTC TGCACCTTCA TGCAGATTGT CATCTGTGTG ATCTGGCTCT ACACCGCGCC CCCCTCAAGC TACCGCAACC AGGAGCTGGA GGATGAGATC ATCTTCATCA CGTGCCACGA GGGCTCCCTC ATGGCCCTGG GCTTCCTGAT CGGCTACACC TGCCTGCTGG CTGCCATCTG CTTCTTCTTT GCCTTCAAGT CCCGGAAGCT GCCGGAGAAC TTCAATGAAG CCAAGTTCAT CACCTTCAGC ATGCTCATCT TCTTCATCGT CTGGATCTCC TTCATTCCAG CCTATGCCAG CACCTATGGC AAGTTTGTCT CTGCCGTAGA GGTGATTGCC ATCCTGGCAG CCAGCTTTGG CTTGCTGGCG TGCATCTTCT TCAACAAGAT CTACATCATT CTCTTCAAGC CATCCCGCAA CACCATCGAG GAGGTGCGTT GCAGCACCGC AGCTCACGCT TTCAAGGTGG CTGCCCGGGC CACGCTGCGC CGCAGCAACG TCTCCCGCAA GCGGTCCAGC AGCCTTGGAG GCTCCACGGG ATCCACCCCC TCCTCCTCCA TCAGCAGCAA GAGCAACAGC GAAGACCCAT TCCCACAGCC CGAGAGGCAG AAGCAGCAGC AGCCGCTGGC CCTAACCCAG CAAGAGCAGC AGCAGCAGCC CCTGACCCTC CCACAGCAGC AACGATCTCA GCAGCAGCCC AGATGCAAGC AGAAGGTCAT CTTTGGCAGC GGCACGGTCA CCTTCTCACT GAGCTTTGAT GAGCCTCAGA AGAACGCCAT GGCCCACAGG AATTCTACGC ACCAGAACTC CCTGGAGGCC CAGAAAAGCA GCGATACGCT GACCCGACAC CAGCCATTAC TCCCGCTGCA GTGCGGGGAA ACGGACTTAG ATCTGACCGT CCAGGAAACA GGTCTGCAAG GACCTGTGGG TGGAGACCAG CGGCCAGAGG TGGAGGACCC TGAAGAGTTG TCCCCAGCAC TTGTAGTGTC CAGTTCACAG AGCTTTGTCA TCAGTGGTGG AGGCAGCACT GTTACAGAAA ACGTAGTGAA TTCATAA. It is sometimes possible for the material contained within the vial of "CASR, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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