CAMK2D cdna clone
CAMK2D cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Uniprot Description
CAMK2D: a protein kinase of the calcium/calmodulin-dependent protein kinase (CAMK) group that interacts with the sarcoplasmic reticulum membrane in cardiac and skeletal muscle. Regulates Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart. Calmodulin binding induces conformational changes that relieve autoinhibition, permitting autophosphorylation at T287, rendering the kinase constitutively active and independent of Ca2+-binding. Targets ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Also targets transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on S2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel SCN5A and the K+ channel Kv4.3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLB), an endogenous inhibitor of SERCA2A, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLB and TRDN, a ryanodine receptor-coupling factor. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2. Ten isoforms of the human protein are produced by alternative splicing. Isoform Delta3, isoform Delta2, isoform Delta8 and isoform Delta9 are expressed in cardiac muscle. Isoform Delta11 is expressed in skeletal muscle. Activity is induced in skeletal muscle during exercise. The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Protein type: CAMK group; CAMK2 family; EC 2.7.11.17; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 4q26
Cellular Component: cytoplasm; cytosol; membrane; neuron projection; nucleoplasm; nucleus; plasma membrane
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Ras guanyl-nucleotide exchange factor activity; sodium channel inhibitor activity; titin binding
Biological Process: cell differentiation; endoplasmic reticulum calcium ion homeostasis; MAPKKK cascade; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein oligomerization; regulation of heart contraction; regulation of the force of heart contraction; regulation of transcription from RNA polymerase II promoter
Research Articles on CAMK2D
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Product Notes
The CAMK2D camk2d (Catalog #AAA1276748) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcttcga ccacaacctg caccaggttc acggacgagt atcagctttt cgaggagctt ggaaaggggg cattctcagt ggtgagaaga tgtatgaaaa ttcctactgg acaagaatat gctgccaaaa ttatcaacac caaaaagctt tctgctaggg atcatcagaa actagaaaga gaagctagaa tctgccgtct tttgaagcac cctaatattg tgcgacttca tgatagcata tcagaagagg gctttcacta cttggtgttt gatttagtta ctggaggtga actgtttgaa gacatagtgg caagagaata ctacagtgaa gctgatgcca gtcattgtat acagcagatt ctagaaagtg ttaatcattg tcacctaaat ggcatagttc acagggacct gaagcctgag aatttgcttt tagctagcaa atccaaggga gcagctgtga aattggcaga ctttggctta gccatagaag ttcaagggga ccagcaggcg tggtttggtt ttgctggcac acctggatat ctttctccag aagttttacg taaagatcct tatggaaagc cagtggatat gtgggcatgt ggtgtcattc tctatattct acttgtgggg tatccaccct tctgggatga agaccaacac agactctatc agcagatcaa ggctggagct tatgattttc catcaccaga atgggacacg gtgactcctg aagccaaaga cctcatcaat aaaatgctta ctatcaaccc tgccaaacgc atcacagcct cagaggcact gaagcaccca tggatctgtc aacgttctac tgttgcttcc atgatgcaca gacaggagac tgtagactgc ttgaagaaat ttaatgctag aagaaaacta aagggtgcca tcttgacaac tatgctggct acaaggaatt tctcagcagc caagagtttg ttgaagaaac cagatggagt aaaggagtca actgagagtt caaatacaac aattgaggat gaagatgtga aagcacgaaa gcaagagatt atcaaagtca ctgaacaact gatcgaagct atcaacaatg gggactttga agcctacaca aaaatctgtg acccaggcct tactgctttt gaacctgaag ctttgggtaa tttagtggaa gggatggatt ttcaccgatt ctactttgaa aatgctttgt ccaaaagcaa taaaccaatc cacactatta ttctaaaccc tcatgtacat ctggtagggg atgatgccgc ctgcatagca tatattaggc tcacacagta catggatggc agtggaatgc caaagacaat gcagtcagaa gagactcgtg tgtggcaccg ccgggatgga aagtggcaga atgttcattt tcatcgctcg gggtcaccaa cagtacccat caagtaa. It is sometimes possible for the material contained within the vial of "CAMK2D, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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