C8A cdna clone
C8A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Uniprot Description
C8A: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: extracellular region; extracellular space; membrane; membrane attack complex
Biological Process: complement activation; immune response; regulation of complement activation
Disease: Complement Component 8 Deficiency, Type I
Research Articles on C8A
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Product Notes
The C8A c8a (Catalog #AAA1278944) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtttgctg ttgttttctt catcttgtct ttgatgactt gtcagcctgg ggtaactgca caggagaagg tgaaccagag agtaagacgg gcagctacac ccgcagcagt tacctgccag ctgagcaact ggtcagagtg gacagattgc tttccgtgcc aggacaaaaa gtaccgacac cggagcctct tgcagccaaa caagtttggg ggaaccatct gcagtggtga catctgggat caagccagct gctccagttc tacaacttgt gtaaggaaag cacagtgtgg acaggatttc cagtgtaagg agacaggtcg ctgcctgaaa cgccaccttg tgtgtaatgg agaccaggac tgccttgatg gctctgatga ggacgactgt gaagatgtca gggccattga cgaagactgc agccagtatg aaccaattcc aggatcacag aaggcagcct tggggtacaa tatcctgacc caggaagatg ctcagagtgt gtacgatgcc agttattatg ggggccagtg tgagacggta tacaatgggg aatggaggga gcttcgatat gactccacct gtgaacgtct ctactatgga gatgatgaga aatactttcg gaaaccctac aactttctga agtaccactt tgaagccctg gcagatactg gaatctcctc agagttttat gataatgcaa atgaccttct ttccaaagtt aaaaaagaca agtctgactc atttggagtg accatcggca taggcccagc cggcagccct ttattggtgg gtgtaggtgt atcccactca caagacactt cattcttgaa cgaattaaac aagtataatg agaagaaatt cattttcaca agaatcttca caaaggtgca gactgcacat tttaagatga ggaaggatga cattatgctg gatgaaggaa tgctgcagtc attaatggag cttccagatc agtacaatta tggcatgtat gccaagttca tcaatgacta tggcacccat tacatcacat ctggatccat gggtggcatt tatgaatata tcctggtgat tgacaaagca aaaatggaat cccttggtat taccagcaga gatatcacga catgttttgg aggctccttg ggcattcaat atgaagacaa aataaatgtt ggtggaggtt tatcaggaga ccattgtaaa aaatttggag gtggcaaaac tgaaagggcc aggaaggcca tggctgtgga agacattatt tctcgggtgc gaggtggcag ttctggctgg agcggtggct tggcacagaa caggagcacc attacatacc gttcctgggg gaggtcatta aagtataatc ctgttgttat cgattttgag atgcagccta tccacgaggt gctgcggcac acaagcctgg ggcctctgga ggccaagcgc cagaacctgc gccgcgcctt ggaccagtat ctgatggaat tcaatgcctg ccgatgtggg ccttgcttca acaatggggt gcccatcctc gagggcacca gctgcaggtg ccagtgccgc ctgggtagct tgggtgctgc ctgtgagcaa acacagacag aaggagccaa agcagatggg agctggagtt gctggagctc ctggtctgta tgcagagcag gcatccagga aaggagaaga gagtgtgaca atccagcacc tcagaatgga ggggcctcgt gtccagggcg gaaagtacag acgcaggctt gctga. It is sometimes possible for the material contained within the vial of "C8A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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