NCBI Description
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Uniprot Description
BMI1: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Component of a PRC1-like complex. Interacts with RING1 and RING2. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1.
Protein type: EC 6.3.2.-; Motility/polarity/chemotaxis; Ubiquitin ligase; Ligase; Oncoprotein; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 10p11.23
Cellular Component: nucleoplasm; nucleus; PcG protein complex; ubiquitin ligase complex
Molecular Function: protein binding; zinc ion binding
Biological Process: hemopoiesis; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; positive regulation of fibroblast proliferation; positive regulation of ubiquitin-protein ligase activity; protein sumoylation; regulation of gene expression; segment specification
Product Notes
The BMI1 bmi1 (Catalog #
AAA1273375) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcatcgaa caacgagaat caagatcact gagctaaatc cccacctgat gtgtgtgctt tgtggagggt acttcattga tgccacaacc ataatagaat gtctacattc cttctgtaaa acgtgtattg ttcgttacct ggagaccagc aagtattgtc ctatttgtga tgtccaagtt cacaagacca gaccactact gaatataagg tcagataaaa ctctccaaga tattgtatac aaattagttc cagggctttt caaaaatgaa atgaagagaa gaagggattt ttatgcagct catccttctg ctgatgctgc caatggctct aatgaagata gaggagaggt tgcagatgaa gataagagaa ttataactga tgatgagata ataagcttat ccattgaatt ctttgaccag aacagattgg atcggaaagt aaacaaagac aaagagaaat ctaaggagga ggtgaatgat aaaagatact tacgatgccc agcagcaatg actgtgatgc acttaagaaa gtttctcaga agtaaaatgg acatacctaa tactttccag attgatgtca tgtatgagga ggaaccttta aaggattatt atacactaat ggatattgcc tacatttata cctggagaag gaatggtcca cttccattga aatacagagt tcgacctact tgtaaaagaa tgaagatcag tcaccagaga gatggactga caaatgctgg agaactggaa agtgactctg ggagtgacaa ggccaacagc ccagcaggag gtattccctc cacctcttct tgtttgccta gccccagtac tccagtgcag tctcctcatc cacagtttcc tcacatttcc agtactatga atggaaccag caacagcccc agcggtaacc accaatcttc ttttgccaat agacctcgaa aatcatcagt aaatgggtca tcagcaactt cttctggttg a.
It is sometimes possible for the material contained within the vial of
"BMI1, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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absolutely not suitable for use in any
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industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
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purchaser may be intending to use a product outside of our accepted criteria.
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aspect of this datasheet at
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