ARNTL cdna clone
ARNTL cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Description
BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus; transcription factor complex
Molecular Function: aryl hydrocarbon receptor binding; DNA binding; Hsp90 protein binding; protein binding; sequence-specific DNA binding
Biological Process: circadian regulation of gene expression; circadian rhythm; negative regulation of fat cell differentiation; negative regulation of TOR signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle; regulation of hair cycle; regulation of insulin secretion; regulation of neurogenesis; regulation of transcription, DNA-dependent; response to redox state; spermatogenesis
Research Articles on ARNTL
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Product Notes
The ARNTL arntl (Catalog #AAA1273372) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGATTAATA TAGAAAGCAT GGACACAGAC AAAGATGACC CTCATGGAAG GTTAGAATAT ACAGAACACC AAGGAAGGAT AAAAAATGCA AGGGAAGCTC ACAGTCAGAT TGAAAAGCGG CGTCGGGATA AAATGAACAG TTTTATAGAT GAATTGGCTT CTTTGGTACC AACATGCAAC GCAATGTCCA GGAAATTAGA TAAACTTACT GTGCTAAGGA TGGCTGTTCA GCACATGAAA ACATTAAGAG GTGCCACCAA TCCATACACA GAAGCAAACT ACAAACCAAC TTTTCTATCA GACGATGAAT TGAAACACCT CATTCTCAGG GCAGCAGATG GATTTTTGTT TGTCGTAGGA TGTGACCGAG GGAAGATACT CTTTGTCTCA GAGTCTGTCT TCAAGATCCT CAACTACAGC CAGAATGATC TGATTGGTCA GAGTTTGTTT GACTACCTGC ATCCTAAAGA TATTGCCAAA GTCAAGGAGC AGCTCTCCTC CTCTGACACC GCACCCCGGG AGCGGCTCAT AGATGCAAAA ACTGGACTTC CAGTTAAAAC AGATATAACC CCTGGGCCAT CTCGATTATG TTCTGGAGCA CGACGTTCTT TCTTCTGTAG GATGAAGTGT AACAGGCCTT CAGTAAAGGT TGAAGACAAG GACTTCCCCT CTACCTGCTC AAAGAAAAAA GCAGATCGAA AAAGCTTCTG CACAATCCAC AGCACAGGCT ATTTGAAAAG CTGGCCACCC ACAAAGATGG GGCTGGATGA AGACAACGAA CCAGACAATG AGGGGTGTAA CCTCAGCTGC CTCGTCGCAA TTGGACGACT GCATTCTCAT GTAGTTCCAC AACCAGTGAA CGGGGAAATC AGGGTGAAAT CTATGGAATA TGTTTCTCGG CACGCGATAG ATGGAAAGTT TGTTTTTGTA GACCAGAGGG CAACAGCTAT TTTGGCATAT TTACCACAAG AACTTCTAGG CACATCGTGT TATGAATATT TTCACCAAGA TGACATAGGA CATCTTGCAG AATGTCATAG GCAAGTTTTA CAGACGAGAG AAAAAATTAC AACTAATTGC TATAAATTTA AAATCAAAGA TGGTTCTTTT ATCACACTAC GGAGTCGATG GTTCAGTTTC ATGAACCCTT GGACCAAGGA AGTAGAATAT ATTGTCTCAA CTAACACTGT TGTTTTAGCC AACGTCCTGG AAGGCGGGGA CCCAACCTTC CCACAGCTCA CAGCATCCCC CCACAGCATG GACAGCATGC TGCCCTCTGG AGAAGGTGGC CCAAAGAGGA CCCACCCCAC TGTTCCAGGG ATTCCAGGGG GAACCCGGGC TGGGGCAGGA AAAATAGGCC GAATGATTGC TGAGGAAATC ATGGAAATCC ACAGGATAAG AGGGTCATCG CCTTCTAGCT GTGGCTCCAG CCCATTGAAC ATCACGAGTA CGCCTCCCCC TGATGCCTCT TCTCCAGGAG GCAAGAAGAT TTTAAATGGA GGGACTCCAG ACATTCCTTC CAGTGGCCTA CTATCAGGCC AGGCTCAGGA GAACCCAGGT TATCCATATT CTGATAGTTC TTCTATTCTT GGTGAGAACC CCCACATAGG TATAGACATG ATTGACAACG ACCAAGGATC AAGTAGTCCC AGTAATGATG AGGCAGCAAT GGCTGTCATC ATGAGCCTCT TGGAAGCAGA TGCTGGACTG GGTGGCCCTG TTGACTTTAG TGACTTGCCA TGGCCGCTGT AA. It is sometimes possible for the material contained within the vial of "ARNTL, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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