ANKHD1 cdna clone
ANKHD1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Sep 2010]
Uniprot Description
ANKHD1: May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Belongs to the mask family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; RNA-binding
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: protein binding
Biological Process: innate immune response
Research Articles on ANKHD1
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Product Notes
The ANKHD1 ankhd1 (Catalog #AAA1271537) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatgtga attcctctaa atacccctca ctgctccttc attcccaaga agaaaagaca agtactgcta cttccaaaac tcagacacga cttgaaggtg aagtgactcc taattccttg tcaaccagct acaagacagt gtcattgcca ttaagctctc caaacataaa gctgaatctc actagcccta aaaggggtca gaaaatagaa gaagggtgga aagaagttgt acgaaggtca aagaaattgt ctgttccagc ctcagtggtg tcgaggataa tgggaagagg aggatgcaac atcactgcaa tacaggatgt tactggtgcc catattgatg tggataaaca aaaagataag aatggcgaga gaatgatcac aataaggggt ggcacagaat caacaagata tgcagttcaa ctaatcaatg cactcattca agatcctgct aaggaactgg aagacttgat tcctaaaaat catatcagaa cacctgccag caccaaatca attcatgcta acttctcatc tggagtaggt accacagcag cttccagtaa aaatgcattt cctttgggtg ctccaactct tgtaacttca caggcaacaa cgttatctac gttccagccc gctaataaac ttaataagaa tgttccaaca aatgtacgtt cttctttccc agtttctcta cccttagctt atcctcaccc tcattttgcc ctgctggctg ctcaaactat gcaacagatt cggcatcctc gcttacccat ggcccagttt ggaggaacct tctcaccttc tcctaacaca tggggaccat tcccagtgag acctgtgaat cctggcaaca caaatagctc tccaaagcat aataacacaa gccgtctacc taaccagaac gggactgttt taccctcaga gtctgctgga ctagctactg ccagttgtcc tatcactgtc tcttctgtag ttgctgccag tcagcaactg tgtgtcacta atacccggac tccttcatca gtcagaaagc agttgtttgc ctgtgtgcct aagacaagtc ctccagcaac agtgatttct tctgtgacaa gcacttgtag ttccctgcct tctgtctcct ctgcacctat cactagcggg caagctccca ccacatttct acctgcaagt acttctcaag cacagctttc ttcacaaaag atggagtctt tctctgctgt gccacccacc aaagagaaag tgtccacaca ggaccagccc atggcaaacc tatgtacccc atcttcaact gcaaacagtt gcagtagctc tgccagcaac accccgggag ctccagaaac tcacccatcc agtagtccca ctcctacttc cagtaacaca caagaggagg cacagccatc cagtgtgtct gatttaagtc ctatgtcaat gccttttgca tctaactcag aacctgctcc attgactttg acatcaccca gaatggttgc tgctgataat caggacacca gtaatttacc tcagttagct gtaccagcac ctcgagtttc tcatcgaatg cagcccagag gttcttttta ctccatggta ccaaatgcaa ctattcacca ggatccccag tctatttttg ttacgaatcc agttacttta acaccacctc aaggcccacc agctgcagtg cagctttctt cagctgtgaa cattatgaat ggttctcaga tgcacataaa cccagcaaat aagtctttgc cacctacatt tggcccagcc acacttttca atcacttcag cagtcttttt gatagtagtc aggtgccagc taaccagggc tggggagatg gtccactgtc ctcacgagtt gctacagatg cctctttcac tgttcagtca gcgttcctgg gtaactcagt gcttggacac ttggaaaaca tgcaccctga taactcaaag gcacctggct tcagaccacc ttcccagcga gtttctacta gtccagttgc cacttctgcc ccaccaacgt tgggccaacc aaaaggagtc agtgccagtc aagatcgaaa gatacctccc ccaattggaa cagagagact ggcccgaatt cggcaaggag ggtctgttgc acaagccccg gcggggacca gttttgtcgc tcccgttgga cacagtggaa tctggtcatt tggtgtcaat gctgtgtcag aaggcttatc aggttggtcg caatctgtga tggggaacca tccaatgcat caacaattat cagacccaag cacattctcc caacatcagc caatggagag agatgattct ggaatggtag ccccctctaa catttttcat cagcctatgg caagtggttt tgtggatttt tctaaaggtc tgccaatttc catgtatgga ggcaccataa taccctctca tcctcagctt gctgatgttc caggaggccc tctgtttaat ggacttcaca atccagatcc tgcttggaac cctatgataa aagttatcca aaattcaact gaatgcactg atgcccagca gatttggcct ggcacgtggg cacctcatat tggaaacatg catctcaaat atgtcaacta a. It is sometimes possible for the material contained within the vial of "ANKHD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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