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ADRB2 cdna clone
ADRB2 cDNA Clone
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Uniprot Description
ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q31-q32
Cellular Component: endosome; integral to plasma membrane; lysosome; plasma membrane; receptor complex
Molecular Function: beta2-adrenergic receptor activity; epinephrine binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein homodimerization activity
Biological Process: adenylate cyclase activation; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; cell-cell signaling; endosome to lysosome transport; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of MAPKKK cascade; positive regulation of protein ubiquitination; receptor-mediated endocytosis; transmembrane receptor protein tyrosine kinase activation (dimerization)
Disease: Asthma, Susceptibility To; Obesity
Research Articles on ADRB2
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Product Notes
The ADRB2 adrb2 (Catalog #AAA1278007) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGGGCAAC CCGGGAACGG CAGCGCCTTC TTGCTGGCAC CCAATAGAAG CCATGCGCCG GACCACGACG TCACGCAGCA AAGGGACGAG GTGTGGGTGG TGGGCATGGG CATCGTCATG TCTCTCATCG TCCTGGCCAT CGTGTTTGGC AATGTGCTGG TCATCACAGC CATTGCCAAG TTCGAGCGTC TGCAGACGGT CACCAACTAC TTCATCACTT CACTGGCCTG TGCTGATCTG GTCATGGGCC TGGCAGTGGT GCCCTTTGGG GCCGCCCATA TTCTTATGAA AATGTGGACT TTTGGCAACT TCTGGTGCGA GTTTTGGACT TCCATTGATG TGCTGTGCGT CACGGCCAGC ATTGAGACCC TGTGCGTGAT CGCAGTGGAT CGCTACTTTG CCATTACTTC ACCTTTCAAG TACCAGAGCC TGCTGACCAA GAATAAGGCC CGGGTGATCA TTCTGATGGT GTGGATTGTG TCAGGCCTTA CCTCCTTCTT GCCCATTCAG ATGCACTGGT ACCGGGCCAC CCACCAGGAA GCCATCAACT GCTATGCCAA TGAGACCTGC TGTGACTTCT TCACGAACCA AGCCTATGCC ATTGCCTCTT CCATCGTGTC CTTCTACGTT CCCCTGGTGA TCATGGTCTT CGTCTACTCC AGGGTCTTTC AGGAGGCCAA AAGGCAGCTC CAGAAGATTG ACAAATCTGA GGGCCGCTTC CATGTCCAGA ACCTTAGCCA GGTGGAGCAG GATGGGCGGA CGGGGCATGG ACTCCGCAGA TCTTCCAAGT TCTGCTTGAA GGAGCACAAA GCCCTCAAGA CGTTAGGCAT CATCATGGGC ACTTTCACCC TCTGCTGGCT GCCCTTCTTC ATCGTTAACA TTGTGCATGT GATCCAGGAT AACCTCATCC GTAAGGAAGT TTACATCCTC CTAAATTGGA TAGGCTATGT CAATTCTGGT TTCAATCCCC TTATCTACTG CCGGAGCCCA GATTTCAGGA TTGCCTTCCA GGAGCTTCTG TGCCTGCGCA GGTCTTCTTT GAAGGCCTAT GGCAATGGCT ACTCCAGCAA CGGCAACACA GGGGAGCAGA GTGGATATCA CGTGGAACAG GAGAAAGAAA ATAAACTGCT GTGTGAAGAC CTCCCAGGCA CGGAAGACTT TGTGGGCCAT CAAGGTACTG TGCCTAGCGA TAACATTGAT TCACAAGGGA GGAATTGTAG TACAAATGAC TCACTGCTAT AA. It is sometimes possible for the material contained within the vial of "ADRB2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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