ADH7 cdna clone
ADH7 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Description
ADH7: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - fatty acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.1.1.1
Chromosomal Location of Human Ortholog: 4q23-q24
Cellular Component: cytosol
Molecular Function: alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; aldehyde oxidase activity; ethanol binding; receptor antagonist activity; retinol binding; retinol dehydrogenase activity
Biological Process: ethanol oxidation; fatty acid omega-oxidation; response to bacterium; response to ethanol; retinoid metabolic process
Research Articles on ADH7
Similar Products
Product Notes
The ADH7 adh7 (Catalog #AAA1273745) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTTTGCAG AAATACAGAT CCAAGACAAA GACAGGATGG GCACTGCTGG AAAAGTTATT AAATGCAAAG CAGCTGTGCT TTGGGAGCAG AAGCAACCCT TCTCCATTGA GGAAATAGAA GTTGCCCCAC CAAAGACTAA AGAAGTTCGC ATTAAGATTT TGGCCACAGG AATCTGTCGC ACAGATGACC ATGTGATAAA AGGAACAATG GTGTCCAAGT TTCCAGTGAT TGTGGGACAT GAGGCAACTG GGATTGTAGA GAGCATTGGA GAAGGAGTGA CTACAGTGAA ACCAGGTGAC AAAGTCATCC CTCTCTTTCT GCCACAATGT AGAGAATGCA ATGCTTGTCG CAACCCAGAT GGCAACCTTT GCATTAGGAG CGATATTACT GGTCGTGGAG TACTGGCTGA TGGCACCACC AGATTTACAT GCAAGGGCAA ACCAGTCCAC CACTTCATGA ACACCAGTAC ATTTACCGAG TACACAGTGG TGGATGAATC TTCTGTTGCT AAGATTGATG ATGCAGCTCC TCCTGAGAAA GTCTGTTTAA TTGGCTGTGG GTTTTCCACT GGATATGGCG CTGCTGTTAA AACTGGCAAG GTCAAACCTG GTTCCACTTG CGTCGTCTTT GGCCTGGGAG GAGTTGGCCT GTCAGTCATC ATGGGCTGTA AGTCAGCTGG TGCATCTAGG ATCATTGGGA TTGACCTCAA CAAAGACAAA TTTGAGAAGG CCATGGCTGT AGGTGCCACT GAGTGTATCA GTCCCAAGGA CTCTACCAAA CCCATCAGTG AGGTGCTGTC AGAAATGACA GGCAACAACG TGGGATACAC CTTTGAAGTT ATTGGGCATC TTGAAACCAT GATTGATGCC CTGGCATCCT GCCACATGAA CTATGGGACC AGCGTGGTTG TAGGAGTTCC TCCATCAGCC AAGATGCTCA CCTATGACCC GATGTTGCTC TTCACTGGAC GCACATGGAA GGGATGTGTC TTTGGAGGTT TGAAAAGCAG AGATGATGTC CCAAAACTAG TGACTGAGTT CCTGGCAAAG AAATTTGACC TGGACCAGTT GATAACTCAT GTTTTACCAT TTAAAAAAAT CAGTGAAGGA TTTGAGCTGC TCAATTCAGG ACAAAGCATT CGAACGGTCC TGACGTTTTG A. It is sometimes possible for the material contained within the vial of "ADH7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
