ACE2 cdna clone
ACE2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Uniprot Description
ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.17.23; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: cell surface; extracellular region; extracellular space; lipid raft; plasma membrane
Molecular Function: carboxypeptidase activity; endopeptidase activity; glycoprotein binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidyl-dipeptidase activity; protein binding; viral receptor activity; zinc ion binding
Biological Process: angiotensin catabolic process in blood; angiotensin maturation; angiotensin mediated drinking behavior; entry of virus into host cell; receptor biosynthetic process; regulation of cell proliferation; regulation of cytokine production; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; virion attachment, binding of host cell surface receptor
Research Articles on ACE2
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Product Notes
The ACE2 ace2 (Catalog #AAA1267807) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCAAGCT CTTCCTGGCT CCTTCTCAGC CTTGTTGCTG TAACTGCTGC TCAGTCCACC ATTGAGGAAC AGGCCAAGAC ATTTTTGGAC AAGTTTAACC ACGAAGCCGA AGACCTGTTC TATCAAAGTT CACTTGCTTC TTGGAATTAT AACACCAATA TTACTGAAGA GAATGTCCAA AACATGAATA ATGCTGGGGA CAAATGGTCT GCCTTTTTAA AGGAACAGTC CACACTTGCC CAAATGTATC CACTACAAGA AATTCAGAAT CTCACAGTCA AGCTTCAGCT GCAGGCTCTT CAGCAAAATG GGTCTTCAGT GCTCTCAGAA GACAAGAGCA AACGGTTGAA CACAATTCTA AATACAATGA GCACCATCTA CAGTACTGGA AAAGTTTGTA ACCCAGATAA TCCACAAGAA TGCTTATTAC TTGAACCAGG TTTGAATGAA ATAATGGCAA ACAGTTTAGA CTACAATGAG AGGCTCTGGG CTTGGGAAAG CTGGAGATCT GAGGTCGGCA AGCAGCTGAG GCCATTATAT GAAGAGTATG TGGTCTTGAA AAATGAGATG GCAAGAGCAA ATCATTATGA GGACTATGGG GATTATTGGA GAGGAGACTA TGAAGTAAAT GGGGTAGATG GCTATGACTA CAGCCGCGGC CAGTTGATTG AAGATGTGGA ACATACCTTT GAAGAGATTA AACCATTATA TGAACATCTT CATGCCTATG TGAGGGCAAA GTTGATGAAT GCCTATCCTT CCTATATCAG TCCAATTGGA TGCCTCCCTG CTCATTTGCT TGGTGATATG TGGGGTAGAT TTTGGACAAA TCTGTACTCT TTGACAGTTC CCTTTGGACA GAAACCAAAC ATAGATGTTA CTGATGCAAT GGTGGACCAG GCCTGGGATG CACAGAGAAT ATTCAAGGAG GCCGAGAAGT TCTTTGTATC TGTTGGTCTT CCTAATATGA CTCAAGGATT CTGGGAAAAT TCCATGCTAA CGGACCCAGG AAATGTTCAG AAAGCAGTCT GCCATCCCAC AGCTTGGGAC CTGGGGAAGG GCGACTTCAG GATCCTTATG TGCACAAAGG TGACAATGGA CGACTTCCTG ACAGCTCATC ATGAGATGGG GCATATCCAG TATGATATGG CATATGCTGC ACAACCTTTT CTGCTAAGAA ATGGAGCTAA TGAAGGATTC CATGAAGCTG TTGGGGAAAT CATGTCACTT TCTGCAGCCA CACCTAAGCA TTTAAAATCC ATTGGTCTTC TGTCACCCGA TTTTCAAGAA GACAATGAAA CAGAAATAAA CTTCCTGCTC AAACAAGCAC TCACGATTGT TGGGACTCTG CCATTTACTT ACATGTTAGA GAAGTGGAGG TGGATGGTCT TTAAAGGGGA AATTCCCAAA GACCAGTGGA TGAAAAAGTG GTGGGAGATG AAGCGAGAGA TAGTTGGGGT GGTGGAACCT GTGCCCCATG ATGAAACATA CTGTGACCCC GCATCTCTGT TCCATGTTTC TAATGATTAC TCATTCATTC GATATTACAC AAGGACCCTT TACCAATTCC AGTTTCAAGA AGCACTTTGT CAAGCAGCTA AACATGAAGG CCCTCTGCAC AAATGTGACA TCTCAAACTC TACAGAAGCT GGACAGAAAC TGTTCAATAT GCTGAGGCTT GGAAAATCAG AACCCTGGAC CCTAGCATTG GAAAATGTTG TAGGAGCAAA GAACATGAAT GTAAGGCCAC TGCTCAACTA CTTTGAGCCC TTATTTACCT GGCTGAAAGA CCAGAACAAG AATTCTTTTG TGGGATGGAG TACCGACTGG AGTCCATATG CAGACCAAAG CATCAAAGTG AGGATAAGCC TAAAATCAGC TCTTGGAGAT AAAGCATATG AATGGAACGA CAATGAAATG TACCTGTTCC GATCATCTGT TGCATATGCT ATGAGGCAGT ACTTTTTAAA AGTAAAAAAT CAGATGATTC TTTTTGGGGA GGAGGATGTG CGAGTGGCTA ATTTGAAACC AAGAATCTCC TTTAATTTCT TTGTCACTGC ACCTAAAAAT GTGTCTGATA TCATTCCTAG AACTGAAGTT GAAAAGGCCA TCAGGATGTC CCGGAGCCGT ATCAATGATG CTTTCCGTCT GAATGACAAC AGCCTAGAGT TTCTGGGGAT ACAGCCAACA CTTGGACCTC CTAACCAGCC CCCTGTTTCC ATATGGCTGA TTGTTTTTGG AGTTGTGATG GGAGTGATAG TGGTTGGCAT TGTCATCCTG ATCTTCACTG GGATCAGAGA TCGGAAGAAG AAAAATAAAG CAAGAAGTGG AGAAAATCCT TATGCCTCCA TCGATATTAG CAAAGGAGAA AATAATCCAG GATTCCAAAA CACTGATGAT GTTCAGACCT CCTTTTAG. It is sometimes possible for the material contained within the vial of "ACE2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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