CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) Recombinant Protein | CDK5RAP2 recombinant protein

Recombinant Human CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) , partial

• Gene Names: CDK5RAP2; C48; MCPH3; Cep215
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: CDK5 regulatory subunit-associated protein 2 (CDK5RAP2); Recombinant Human CDK5 regulatory subunit-associated protein 2 (CDK5RAP2); partial; CDK5RAP2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1814

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CDK5RAP2 recombinant protein

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. This protein binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein may also be a substrate of neuronal CDC2-like kinase. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 58535453
• NCBI GeneID: 55755
• NCBI Accession #: NP_001011649.1
• NCBI GenBank Nucleotide #: NM_001011649.2
• UniProt Accession #: Q96SN8; Q5JV18; Q7Z3L4; Q7Z3U1; Q7Z7I6; Q9BSW0; Q9H6J6; Q9HCD9; Q9NV90; Q9UIW9
• Molecular Weight: 206,323 Da
• NCBI Official Full Name: CDK5 regulatory subunit-associated protein 2 isoform b
• NCBI Official Synonym Full Names: CDK5 regulatory subunit associated protein 2
• NCBI Official Symbol: CDK5RAP2
• NCBI Official Synonym Symbols: C48; MCPH3; Cep215
• NCBI Protein Information: CDK5 regulatory subunit-associated protein 2
• UniProt Protein Name: CDK5 regulatory subunit-associated protein 2
• Protein Family: CDK5 regulatory subunit-associated protein
• UniProt Gene Name: CDK5RAP2
• UniProt Synonym Gene Names: CEP215; KIAA1633

NCBI Description

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Description

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis ().