Rat Cyclin-dependent kinase 5 activator 1 ELISA Kit | Cdk5r1 elisa kit
Rat Cyclin-dependent kinase 5 activator 1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
kinase that phosphorylates neurofilament protein (NF-H)and intermediate filament protein nestin [RGD, Feb 2006]
Uniprot Description
CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: axon; cell soma; contractile fiber; cyclin-dependent protein kinase 5 activator complex; cytoplasm; dendrite; dendritic spine; growth cone; intracellular membrane-bound organelle; membrane; neuromuscular junction; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic density
Molecular Function: cadherin binding; calcium ion binding; cyclin-dependent protein kinase 5 activator activity; ephrin receptor binding; kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activator activity
Biological Process: acetylcholine receptor signaling, muscarinic pathway; axon extension; axon guidance; axonal fasciculation; brain development; cerebellum development; cerebral cortex radially oriented cell migration; ephrin receptor signaling pathway; hippocampus development; ionotropic glutamate receptor signaling pathway; layer formation in the cerebral cortex; negative regulation of axon extension; negative regulation of transcription, DNA-dependent; neurite development; neuron adhesion; neuron differentiation; neuron migration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of neuron apoptosis; positive regulation of protein kinase activity; regulation of actin cytoskeleton organization and biogenesis; serine phosphorylation of STAT protein; superior olivary nucleus maturation
Research Articles on Cdk5r1
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Product Notes
The Rat Cdk5r1 cdk5r1 (Catalog #AAA9427471) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9427471 ELISA Kit recognizes Rat Cdk5r1. It is sometimes possible for the material contained within the vial of "Cyclin-dependent kinase 5 activator 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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