Cyclin Dependent Kinase 11B Recombinant Protein | CDK11B recombinant protein
Recombinant Cyclin Dependent Kinase 11B (CDK11B)
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
Accurate Molecular Mass: 37kDa
Uniprot Description
CDK11B: a protein kinase of the CDK family. May act as a negative regulator of the normal cell cycle progression. Nine alternatively spliced isoforms have been described. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. 2 isoforms, SV9 and 7, are produced by alternative initiation at Met-1 and Met-357 resulting in p110 and p58 isoforms, respectively. Deleted or altered frequently in neuroblastoma with amplified MYCN genes. Can be cleaved by caspases and demonstrated to play a role in cell apoptosis.
Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Apoptosis; EC 2.7.11.22; Protein kinase, CMGC; Motility/polarity/chemotaxis; CMGC group; CDK family; PITSLRE subfamily; CDK/PITSLRE subfamily
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity
Biological Process: cell proliferation; mitosis; regulation of transcription, DNA-dependent; apoptosis; regulation of cell cycle; regulation of cell growth; protein amino acid phosphorylation; regulation of mRNA processing
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Product Notes
The CDK11B cdk11b (Catalog #AAA2123273) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Phe438~Arg724. AAA Biotech's Cyclin Dependent Kinase 11B can be used in a range of immunoassay formats including, but not limited to, Positive Control, Immunogen, SDS-PAGE, Western Blot (WB). Researchers should empirically determine the suitability of the CDK11B cdk11b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin Dependent Kinase 11B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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