APC/C activator protein CDH1 (CDH1) Recombinant Protein | CDH1 recombinant protein

Recombinant Saccharomyces cerevisiae APC/C activator protein CDH1 (CDH1) , partial

• Gene Names: CDH1; HCT1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: APC/C activator protein CDH1 (CDH1); Recombinant Saccharomyces cerevisiae APC/C activator protein CDH1 (CDH1); partial; CDH1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 566

• Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 6321435
• NCBI GeneID: 852881
• NCBI Accession #: NP_011512.1
• NCBI GenBank Nucleotide #: NM_001180868.1
• UniProt Accession #: P53197; D6VUD5
• Molecular Weight: 62,821 Da
• NCBI Official Full Name: Cdh1p
• NCBI Official Symbol: CDH1
• NCBI Official Synonym Symbols: HCT1
• NCBI Protein Information: Cdh1p
• UniProt Protein Name: APC/C activator protein CDH1
• Protein Family: APC/C activator protein
• UniProt Gene Name: CDH1
• UniProt Synonym Gene Names: HCT1

Uniprot Description

Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway.