Human CDC14 cell division cycle 14 homolog B (S. cerevisiae) ELISA Kit | CDC14B elisa kit
Human Dual specificity protein phosphatase CDC14B, CDC14B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
CDC14B: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.48; EC 3.1.3.16; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; Nucleolus
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: nucleoplasm; nuclear membrane; nucleolus; nucleus
Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity
Biological Process: anaphase-promoting complex activation; DNA repair; protein amino acid dephosphorylation; G2/M transition DNA damage checkpoint
Research Articles on CDC14B
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Product Notes
The Human CDC14B cdc14b (Catalog #AAA9341461) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341461 ELISA Kit recognizes Human CDC14B. It is sometimes possible for the material contained within the vial of "CDC14 cell division cycle 14 homolog B (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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