CD93 / C1QR1 recombinant protein

Recombinant Human CD93 / C1QR1 Protein (Fc tag)

Cat. Num. AAA2545477

• Gene Names: CD93; C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
• Purity: > 85 % as determined by SDS-PAGE
• Synonyms: CD93 / C1QR1; Recombinant Human CD93 / C1QR1 Protein (Fc tag); C1QR1; C1qR (P); C1qRP; CDw93; ECSM3; MXRA4; dJ737E23.1; CD93 / C1QR1 recombinant protein

• Host: Human Cells
• Purity/Purification: > 85 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 652

• Application Notes: The recombinant human CD93/Fc is a disulfide-linked homodimer. The reduced monomer consists of 800 amino acids after removal the signal peptide and has a predicted molecular mass of 85.2 kDa. As a result of glycosylation, rh CD93/Fc monomer migrates as an approximately 125 kDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Thr 22
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CD93 / C1QR1 recombinant protein

Background: CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype -switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

Description: A DNA sequence encoding the human CD93 (Q9NPY3) extracellular domain (Met 1-Lys 580) was fused with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 88758613
• NCBI GeneID: 22918
• NCBI Accession #: NP_036204.2
• NCBI GenBank Nucleotide #: NM_012072.3
• UniProt Accession #: Q9NPY3; O00274
• Molecular Weight: 68,560 Da
• NCBI Official Full Name: complement component C1q receptor
• NCBI Official Synonym Full Names: CD93 molecule
• NCBI Official Symbol: CD93
• NCBI Official Synonym Symbols: C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
• NCBI Protein Information: complement component C1q receptor
• UniProt Protein Name: Complement component C1q receptor
• UniProt Gene Name: CD93
• UniProt Synonym Gene Names: C1QR1; MXRA4; C1qR; C1qR(p); C1qRp

NCBI Description

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]

Uniprot Description

CD93: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular matrix; integral to membrane; plasma membrane

Molecular Function: complement component C1q binding; protein binding

Biological Process: cell-cell adhesion