CD44 antigen (Cd44) Recombinant Protein | Cd44 recombinant protein
Recombinant Mouse CD44 antigen (Cd44)
NCBI and Uniprot Product Information
Uniprot Description
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.
Cellular Component: Golgi apparatus; protein complex; cell surface; focal adhesion; membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; hyalurononglucosaminidase activity; epidermal growth factor receptor binding
Biological Process: cell migration; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; regulation of cell growth; cell adhesion; healing during inflammatory response; neurite development; positive regulation of adaptive immune response; negative regulation of apoptosis
Research Articles on Cd44
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Product Notes
The Cd44 cd44 (Catalog #AAA952992) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-685. Fragment at the N-terminal, provide the complete extracellular domain. The amino acid sequence is listed below: QIDLNVTCRY AGVFHVEKNG RYSISRTEAA DLCQAFNSTL PTMDQMKLAL SKGFETCRYG FIEGNVVIPR IHPNAICAAN HTGVYILVTS NTSHYDTYCF NASAPPEEDC TSVTDLPNSF DGPVTITIVN RDGTRYSKKG EYRTHQEDID ASNIIDDDVS SGSTIEKSTP EGYILHTYLP TEQPTGDQDD SFFIRSTLAT IASTVHSKSH AAAQKQNNWI WSWFGNSQST TQTQEPTTSA TTALMTTPET PPKRQEAQNW FSWLFQPSES KSHLHTTTKM PGTESNTNPT GWEPNEENED ETDTYPSFSG SGIDDDEDFI SSTIATTPRV SARTEDNQDW TQWKPNHSNP EVLLQTTTRM ADIDRISTSA HGENWTPEPQ PPFNNHEYQD EEETPHATST TPNSTAEAAA TQQETWFQNG WQGKNPPTPS EDSHVTEGTT ASAHNNHPSQ RITTQSQEDV SWTDFFDPIS HPMGQGHQTE SKDTDSSHST TLQPTAAPNT HLVEDLNRTG PLSVTTPQSH SQNFSTLHGE PEEDENYPTT SILPSSTKSS AKDARRGGSL PTDTTTSVEG YTFQYPDTME NGTLFPVTPA KTEVFGETEV TLATDSNVNV DGSLPGDRDS SKDSRGSSRT VTHGSELAGH SSANQDSGVT TTSGPMRRPQ IPE . It is sometimes possible for the material contained within the vial of "CD44 antigen (Cd44), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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