Sialic Acid Binding Ig-like Lectin 3 Recombinant Protein | Cd33 recombinant protein

Recombinant Mouse Sialic Acid Binding Ig-like Lectin 3 Protein

Cat. Num. AAA2556764

• Gene Names: Cd33; gp67; Siglec-3
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Sialic Acid Binding Ig-like Lectin 3; Recombinant Mouse Sialic Acid Binding Ig-like Lectin 3 Protein; CD33; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; Siglec3; Cd33 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Length: 403

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Met 1-Glu 240
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for Cd33 recombinant protein

Protein Construction: Recombinant Mouse Sialic Acid Binding Ig-like Lectin 3 is produced by our Mammalian expression system and the target gene encoding Asp18-Glu240 is expressed with a 6His tag at the C-terminus.

Background: Mouse myeloid cell surface antigen CD33(CD33) is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 contains one Ig-like C2-type domain and one Ig-like V-type domain. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia. CD33 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).

NCBI and Uniprot Product Information

• NCBI GI #: 161484603
• NCBI GeneID: 12489
• NCBI Accession #: NP_001104528.1
• NCBI GenBank Nucleotide #: NM_001111058.1
• UniProt Accession #: Q63994; Q63997; A2RT59
• Molecular Weight: Molecular Mass: 25.7kDa; Actual Protein Molecular Mass: 40kDa
• NCBI Official Full Name: myeloid cell surface antigen CD33 isoform 1
• NCBI Official Synonym Full Names: CD33 antigen
• NCBI Official Symbol: Cd33
• NCBI Official Synonym Symbols: gp67; Siglec-3
• NCBI Protein Information: myeloid cell surface antigen CD33
• UniProt Protein Name: Myeloid cell surface antigen CD33
• Protein Family: Myeloid cell surface antigen
• UniProt Gene Name: Cd33
• UniProt Synonym Gene Names: Siglec3; Siglec-3

Uniprot Description

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (). Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563).