CD300LB recombinant protein

CD300LB Protein, Human, Recombinant (ECD, hFc Tag)

Cat. Num. AAA8121492

• Gene Names: CD300LB; CLM7; CLM-7; IREM3; TREM5; CD300b; IREM-3; TREM-5; CMRF35-A2
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CD300LB; CD300LB Protein; Human; Recombinant (ECD; hFc Tag); Human CD300LB/LMIR5/CMRF35-A2 Protein (Fc Tag; ECD); CD300b Protein; CLM-7 Protein; CLM7 Protein; CMRF35-A2 Protein; IREM-3 Protein; IREM3 Protein; TREM-5 Protein; TREM5 Protein; CD300 molecule-like family member b; CD300LB recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Tyr151

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Ile 18
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human CD300LB (NP_777552.3)(Met1-Tyr151) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Product Categories/Family for CD300LB recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

NCBI and Uniprot Product Information

• NCBI GI #: 510936990
• NCBI GeneID: 124599
• NCBI Accession #: NP_777552.3
• NCBI GenBank Nucleotide #: NM_174892.3
• UniProt Accession #: A8K4G0; Q1EG73; Q8IX40; Q8N6D1
• Molecular Weight: 22,689 Da
• NCBI Official Full Name: CMRF35-like molecule 7
• NCBI Official Synonym Full Names: CD300 molecule-like family member b
• NCBI Official Symbol: CD300LB
• NCBI Official Synonym Symbols: CLM7; CLM-7; IREM3; TREM5; CD300b; IREM-3; TREM-5; CMRF35-A2
• NCBI Protein Information: CMRF35-like molecule 7; leukocyte mono-Ig-like receptor 5; CD300 antigen like family member B; immune receptor expressed on myeloid cells 3; triggering receptor expressed on myeloid cells 5
• UniProt Protein Name: CMRF35-like molecule 7
• Protein Family: CMRF35-like molecule
• UniProt Gene Name: CD300LB
• UniProt Synonym Gene Names: CD300B; CLM7; CMRF35A2; IREM3; LMIR5; TREM5; CLM-7; IREM-3; TREM-5
• UniProt Entry Name: CLM7_HUMAN

NCBI Description

CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]

Uniprot Description

Function: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. Ref.1 Ref.9

Subunit structure: Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN. Ref.1 Ref.9

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Expressed exclusively in myeloid lineages. Ref.1

Post-translational modification: Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.

Sequence similarities: Belongs to the CD300 family.Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence caution: The sequence AAH28091.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAF83614.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence EAW89170.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.