CD1D recombinant protein

Human CD1D Protein, hFc Tag

Cat. Num. AAA188562

• Gene Names: CD1D; R3; CD1A
• Purity: Affinity purification
• Synonyms: CD1D; Human CD1D Protein; hFc Tag; CD1A; R3; R3G1; CD1D recombinant protein

• Host: HEK293 cells
• Purity/Purification: Affinity purification
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization.
• Sequence: CD1D (Gln20-Ser301) + hFc (GLU99-ALA330)

• Origin: Human
• Reconstitution: Reconstitute with deionized water
• Tag: C-Human Fc
• Preparation and Storage: Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)

Related Product Information for CD1D recombinant protein

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

NCBI and Uniprot Product Information

• NCBI GI #: 115964
• NCBI GeneID: 912
• UniProt Accession #: P15813; Q5W0J3; Q9UMM3; Q9Y5M4; D3DVD5
• Molecular Weight: 335
• NCBI Official Full Name: Antigen-presenting glycoprotein CD1d
• NCBI Official Synonym Full Names: CD1d molecule
• NCBI Official Symbol: CD1D
• NCBI Official Synonym Symbols: R3; CD1A
• NCBI Protein Information: antigen-presenting glycoprotein CD1d; R3G1; thymocyte antigen CD1D; CD1D antigen, d polypeptide; T-cell surface glycoprotein CD1d; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D
• UniProt Protein Name: Antigen-presenting glycoprotein CD1d
• Protein Family: Antigen-presenting glycoprotein
• UniProt Gene Name: CD1D
• UniProt Entry Name: CD1D_HUMAN

NCBI Description

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Uniprot Description

CD1D: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.

Protein type: Apoptosis; Membrane protein, integral; Lipid-binding; Cell surface

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: cell surface; lysosomal membrane; integral to plasma membrane; cytoplasm; endosome membrane

Molecular Function: histone binding; beta-2-microglobulin binding; exogenous lipid antigen binding; lipid antigen binding; cell adhesion molecule binding; receptor activity; endogenous lipid antigen binding

Biological Process: antigen processing and presentation, endogenous lipid antigen via MHC class Ib; heterotypic cell-cell adhesion; detection of bacterium; viral reproduction; positive regulation of innate immune response; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; T cell selection; innate immune response; positive regulation of T cell proliferation