Carbonyl Reductase-3 Recombinant Protein | CBR3 recombinant protein
Recombinant Human Carbonyl Reductase-3
Gene Names
CBR3; hCBR3; SDR21C2; HEL-S-25
Purity
Greater than 95.0% as determined by analysis by SDS-PAGE.
Synonyms
Carbonyl Reductase-3; Recombinant Human Carbonyl Reductase-3; CBR3 Human; Carbonyl Reductase-3 Human Recombinant; Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; CBR3; carbonyl reductase 3; hCBR3; SDR21C2; CBR3 recombinant protein
Host
Escherichia Coli
Purity/Purification
Greater than 95.0% as determined by analysis by SDS-PAGE.
Form/Format
The CBR3 protein solution (1mg/mL) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Sequence
MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW
Sequence Length
277
Physical Appearance
Sterile filtered colorless solution.
Preparation and Storage
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Related Product Information for CBR3 recombinant protein
Description: Recombinant Human CBR3 fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids (1-277 a.a) and having a molecular mass of 33kDa.
CBR3 is purified by proprietary chromatographic techniques.
Introduction: CBR3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. CBR3 is one of several monomeric NADPH-dependent oxidoreductases. Furthermore, CBR3 contains 3 exons spanning 11.2 kilobases and is strongly linked to another carbonyl reductase gene, the CBR1. It was suggested that CBR3 mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.CBR3 is identified in the ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and the testis.Polymorphisms in CBR3 may give an explanation to interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics.
CBR3 is purified by proprietary chromatographic techniques.
Introduction: CBR3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. CBR3 is one of several monomeric NADPH-dependent oxidoreductases. Furthermore, CBR3 contains 3 exons spanning 11.2 kilobases and is strongly linked to another carbonyl reductase gene, the CBR1. It was suggested that CBR3 mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.CBR3 is identified in the ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and the testis.Polymorphisms in CBR3 may give an explanation to interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
carbonyl reductase
NCBI Official Synonym Full Names
carbonyl reductase 3
NCBI Official Symbol
CBR3
NCBI Official Synonym Symbols
hCBR3; SDR21C2; HEL-S-25
NCBI Protein Information
carbonyl reductase [NADPH] 3; carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; carbonyl reductase (NADPH) 3; epididymis secretory protein Li 25; short chain dehydrogenase/reductase family 21C, member 2
UniProt Protein Name
Carbonyl reductase [NADPH] 3
Protein Family
UniProt Gene Name
CBR3
UniProt Entry Name
CBR3_HUMAN
NCBI Description
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
Uniprot Description
CBR3: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.1.1.184
Chromosomal Location of Human Ortholog: 21q22.2
Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol
Molecular Function: 3-keto sterol reductase activity; carbonyl reductase (NADPH) activity
Biological Process: phylloquinone catabolic process; cognition
Research Articles on CBR3
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Product Notes
The CBR3 cbr3 (Catalog #AAA143571) is a Recombinant Protein produced from Escherichia Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW. It is sometimes possible for the material contained within the vial of "Carbonyl Reductase-3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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