Human core-binding factor, runt domain, alpha subunit 2; translocated to, 2 ELISA Kit | CBFA2T2 elisa kit
Human Protein CBFA2T2, CBFA2T2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
CBFA2T2: May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Belongs to the CBFA2T family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 20q11
Cellular Component: nucleus
Molecular Function: protein binding; metal ion binding; transcription corepressor activity; transcription factor activity
Biological Process: epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on CBFA2T2
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Product Notes
The Human CBFA2T2 cbfa2t2 (Catalog #AAA9327112) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327112 ELISA Kit recognizes Human CBFA2T2. It is sometimes possible for the material contained within the vial of "core-binding factor, runt domain, alpha subunit 2; translocated to, 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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