Cat Kalirin (KALRN) ELISA Kit | KALRN elisa kit

Cat Kalirin (KALRN) ELISA Kit

• Gene Names: Kalrn; Duo; Hapip; Kalirin
• Reactivity: Cat
• Synonyms: Kalirin (KALRN); Cat Kalirin (KALRN) ELISA Kit; KALRN elisa kit

• Reactivity: Cat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 295054252
• NCBI GeneID: 84009
• NCBI Accession #: NP_114451.2
• NCBI GenBank Nucleotide #: NM_032062.2
• Molecular Weight: 81,973 Da
• NCBI Official Full Name: kalirin
• NCBI Official Synonym Full Names: kalirin, RhoGEF kinase
• NCBI Official Symbol: Kalrn
• NCBI Official Synonym Symbols: Duo; Hapip; Kalirin
• NCBI Protein Information: kalirin
• UniProt Protein Name: Kalirin
• Protein Family: Kalirin
• UniProt Gene Name: Kalrn
• UniProt Synonym Gene Names: Duo; Hapip; P-CIP10
• UniProt Entry Name: KALRN_RAT

NCBI Description

binds the human huntingtin associated protein Hap1 in vitro; has GDP/GTP exchange factor activity for Rho subfamily GTP-binding proteins [RGD, Feb 2006]

Uniprot Description

kalirin: a bifunctional enzyme with protein kinase activity and guanine-exchange factor (GEF) activity. A protein kinase of the CAMK group. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Genetic variants are associated with susceptibility to coronary heart disease type 5 (CHDS5), a multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) Interacts with FASLG. The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity. 6 isoforms of the human protein are produced by alternative splicing. Isoform 2 is brain specific and is highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.

Protein type: Kinase, protein; GEFs, Rac/Rho; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; GEFs; CAMK group; Trio family

Cellular Component: cell soma; cytoskeleton; neuron projection; perinuclear region of cytoplasm

Molecular Function: ATP binding; enzyme binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: axonogenesis; nervous system development; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of dendrite development; regulation of Rho protein signal transduction