Calnexin Recombinant Protein | CANX recombinant protein

Calnexin, 21-481aa, Human, E Coli

Cat. Num. AAA203389

• Gene Names: CANX; CNX; P90; IP90
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: Calnexin; 21-481aa; Human; E Coli; CNX; IP90; P90; CANX; FLJ26570; Histocompatibility complex class I antigen binding protein p88; ; CANX recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT and 20% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MHDGHDDDVI DIEDDLDDVI EEVEDSKPDT TAPPSSPKVT YKAPVPTGEV YFADSFDRGT LSGWILSKAK KDDTDDEIAK YDGKWEVEEM KESKLPGDKG LVLMSRAKHH AISAKLNKPF LFDTKPLIVQ YEVNFQNGIE CGGAYVKLLS KTPELNLDQF HDKTPYTIMF GPDKCGEDYK LHFIFRHKNP KTGIYEEKHA KRPDADLKTY FTDKKTHLYT LILNPDNSFE ILVDQSVVNS GNLLNDMTPP VNPSREIEDP EDRKPEDWDE RPKIPDPEAV KPDDWDEDAP AKIPDEEATK PEGWLDDEPE YVPDPDAEKP EDWDEDMDGE WEAPQIANPR CESAPGCGVW QRPVIDNPNY KGKWKPPMID NPSYQGIWKP RKIPNPDFFE DLEPFRMTPF SAIGLELWSM TSDIFFDNFI ICADRRIVDD WANDGWGLKK AADGAAEPGV VGQMIEAAEE RP
• Sequence Length: 592

• Applicable Applications for CANX recombinant protein: SDS-PAGE
• Antigen Species: Human
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for CANX recombinant protein

Calnexin, also known as IP90, p88 and p90, is a member of the calnexin family of molecular chaperones. This protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Recombinant Calnexin protein was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for CANX recombinant protein

Heat Shock Proteins

References

Wang B., et al. (2009) Immunology. 128 (1):43-57. ; Millar DJ., et al. (2009) Proteomics. 9 (9):2355-72.;

NCBI and Uniprot Product Information

• NCBI GI #: 66933005
• NCBI GeneID: 821
• NCBI Accession #: NP_001019820
• NCBI GenBank Nucleotide #: NM_001024649.1
• UniProt Accession #: P27824; B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3
• Molecular Weight: 52.5 kDa (462aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
• NCBI Official Full Name: calnexin
• NCBI Official Synonym Full Names: calnexin
• NCBI Official Symbol: CANX
• NCBI Official Synonym Symbols: CNX; P90; IP90
• NCBI Protein Information: calnexin
• UniProt Protein Name: Calnexin
• Protein Family: Calnexin
• UniProt Gene Name: CANX

NCBI Description

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.